Comprehensive medication guide to AirDuo RespiClick including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–30 copay for the authorized generic on most commercial and Medicare Part D plans; typically Tier 1–2 on formulary. Prior authorization may be required if switching to a different ICS/LABA class.
Estimated Cash Pricing
$100–165 retail for the authorized generic (Fluticasone Propionate/Salmeterol MDPI) per 60-dose inhaler; as low as $55–72 with a GoodRx or SingleCare coupon for a 30-day supply. The brand-name AirDuo RespiClick is discontinued.
Medfinder Findability Score
45/100
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AirDuo RespiClick was a brand-name combination asthma maintenance inhaler manufactured by Teva Respiratory. It contained two active ingredients: fluticasone propionate (an inhaled corticosteroid) and salmeterol (a long-acting beta-2 agonist). It was delivered via the RespiClick breath-activated multidose dry powder inhaler (MDPI) and was FDA-approved for maintenance treatment of asthma in patients 12 years and older.
Teva discontinued the AirDuo RespiClick brand on July 9, 2025 — not due to a safety issue, but as a business decision. The authorized generic — Fluticasone Propionate and Salmeterol Inhalation Powder (MDPI), also by Teva — continues to be manufactured in all three original strengths: 55/14 mcg, 113/14 mcg, and 232/14 mcg.
AirDuo is used twice daily as maintenance therapy and should never be used as a rescue inhaler. It does not work fast enough to treat sudden asthma attacks.
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AirDuo's two components address the two primary mechanisms of asthma. Fluticasone propionate is a corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors in lung tissue, suppressing the production of inflammatory proteins (cytokines, leukotrienes) that cause airway swelling and mucus overproduction. This anti-inflammatory effect builds gradually over days to weeks of consistent use.
Salmeterol is a long-acting beta-2 agonist (LABA) that relaxes the smooth muscle cells surrounding the airways by activating beta-2 adrenergic receptors and increasing cyclic AMP (cAMP) levels inside the cells. This muscle relaxation widens the airways and improves airflow for up to 12 hours per dose — which is why the medication is taken twice daily, approximately 12 hours apart.
The ICS and LABA components work synergistically: fluticasone upregulates beta-2 receptor expression (making airways more responsive to salmeterol), while salmeterol may enhance fluticasone's anti-inflammatory effects. Clinical trials confirm that combination ICS/LABA therapy provides better asthma control than either drug alone.
55 mcg / 14 mcg — dry powder inhaler (MDPI)
Low-dose strength for less severe asthma or patients new to ICS/LABA therapy. 1 inhalation twice daily.
113 mcg / 14 mcg — dry powder inhaler (MDPI)
Medium-dose strength, most commonly prescribed. 1 inhalation twice daily.
232 mcg / 14 mcg — dry powder inhaler (MDPI)
High-dose strength for patients with greater asthma severity. Maximum recommended dose. 1 inhalation twice daily.
The brand-name AirDuo RespiClick is no longer available anywhere — Teva discontinued distribution on July 9, 2025. If you search for "AirDuo RespiClick" specifically, pharmacies will tell you it's unavailable. However, the authorized generic (Fluticasone Propionate and Salmeterol Inhalation Powder, MDPI) remains in production and is stocked at most pharmacies.
Availability of the authorized generic varies by pharmacy. Not every pharmacy carries every strength, and some patients in certain areas may encounter difficulty finding their specific dose. Equivalent options (Advair Diskus, Wixela Inhub) are more widely stocked at most chain pharmacies.
To find the authorized generic or an equivalent inhaler at a pharmacy near you, use medfinder. medfinder contacts pharmacies on your behalf and texts you results — no hold music, no driving around empty-handed.
Fluticasone propionate/salmeterol is not a controlled substance. It can be prescribed by any licensed healthcare provider without DEA special registration. Prescriptions can be written, electronically submitted, or phoned in to any pharmacy.
Prescriber types who commonly order AirDuo and its equivalents:
Since fluticasone/salmeterol is not a controlled substance, it can be prescribed via telehealth in all 50 states. Patients with a confirmed asthma diagnosis who need a prescription refill or an updated prescription (to switch from the discontinued brand to the authorized generic) can often handle this via a telehealth visit without an in-person appointment.
No. AirDuo RespiClick and its authorized generic (fluticasone propionate/salmeterol MDPI) are not controlled substances. They are not scheduled under the DEA's Controlled Substances Act. This means:
Most common side effects reported in clinical trials:
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Fluticasone/Salmeterol MDPI (Authorized Generic)
Exact same drug as AirDuo RespiClick — same formulation, same inhaler device. No dosing adjustment needed. Made by Teva.
Advair Diskus / Advair HFA
Same active ingredients (fluticasone propionate/salmeterol) in different inhaler formats. GSK caps monthly costs at $35 for commercially insured patients.
Wixela Inhub
Generic fluticasone/salmeterol in a Diskus inhaler. Savings card available: $10/month for commercially insured patients.
Symbicort (budesonide/formoterol)
ICS/LABA combination using different active ingredients. Available in generic. Widely covered on formularies. Pressurized MDI.
Breo Ellipta (fluticasone furoate/vilanterol)
Once-daily ICS/LABA combination. Different fluticasone compound. Good adherence profile due to once-daily dosing.
Prefer AirDuo RespiClick? We can find it.
Strong CYP3A4 inhibitors (ritonavir, ketoconazole)
majorDramatically increase fluticasone blood levels, causing excessive corticosteroid exposure and adrenal suppression. Concomitant use not recommended.
Other LABA medications (formoterol, vilanterol, indacaterol)
majorConcurrent use of two LABAs significantly increases cardiovascular toxicity risk (arrhythmia, tachycardia). Never combine.
MAO inhibitors (phenelzine, tranylcypromine)
majorAmplify salmeterol's cardiovascular effects. Avoid within 14 days of MAOI use.
Beta-blockers (propranolol, metoprolol)
majorNon-selective beta-blockers block salmeterol's bronchodilator effect and may cause bronchospasm. Cardioselective beta-blockers are preferred if necessary.
Loop/thiazide diuretics (furosemide, hydrochlorothiazide)
moderateCan worsen hypokalemia and ECG changes when combined with salmeterol.
Tricyclic antidepressants (amitriptyline, nortriptyline)
moderatePotentiate cardiovascular effects of salmeterol. Use with caution.
While the AirDuo RespiClick brand is gone, the medication it delivered is not. The authorized generic — Fluticasone Propionate and Salmeterol Inhalation Powder (MDPI) by Teva — uses the exact same formulation and device. Most patients should be able to transition seamlessly, and in many cases will pay less since insurance plans often cover generics at a lower tier than brand medications.
For patients who truly cannot access the authorized generic in their area, Advair Diskus, Wixela Inhub, Symbicort, and Breo Ellipta are all clinically appropriate alternatives. The key is communicating clearly with your prescriber about the change and ensuring your new prescription is written in a way that pharmacies can fill.
If you're having trouble locating fluticasone/salmeterol at a pharmacy near you, medfinder can take the guesswork out of the search. Enter your medication and location, and medfinder will contact nearby pharmacies and text you results. No hold music, no wasted trips.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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