What Is Zenzedi?

Zenzedi is a brand-name prescription medication containing Dextroamphetamine Sulfate, a central nervous system (CNS) stimulant used to treat ADHD and narcolepsy.

Manufactured by Azurity Pharmaceuticals (formerly Arbor Pharmaceuticals), Zenzedi is an immediate-release oral tablet available in seven strengths: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, and 30 mg. It is classified as a Schedule II controlled substance by the DEA, meaning it has a recognized medical use but also a high potential for abuse and dependence.

Dextroamphetamine — the active ingredient — is the dextro-isomer of amphetamine, which means it's more potent at stimulating dopamine signaling in the brain compared to the levo-isomer. This makes it a particularly focused stimulant. For a deeper dive into how this works at the brain level, see our article on how Zenzedi works.

What Is Zenzedi Used For?

FDA-Approved Uses

• ADHD (Attention Deficit Hyperactivity Disorder) — Zenzedi is FDA-approved for treating ADHD in pediatric patients ages 3–16. It helps improve focus, reduce impulsivity, and manage hyperactivity.
• Narcolepsy — Zenzedi is also approved for narcolepsy, a sleep disorder that causes excessive daytime sleepiness and sudden sleep attacks.

Off-Label Uses

While not FDA-approved for these uses, doctors sometimes prescribe Dextroamphetamine for:

• Adult ADHD — Many adults take Zenzedi or generic Dextroamphetamine for ADHD, even though the FDA approval is for pediatric patients.
• Treatment-resistant depression — As an add-on to antidepressants in cases where standard treatments haven't worked.
• Excessive daytime sleepiness — Beyond narcolepsy, for conditions causing persistent sleepiness.

How Is Zenzedi Taken?

Zenzedi is taken by mouth, typically 1 to 3 times daily at 4- to 6-hour intervals. Here's what you need to know about taking it:

• First dose in the morning — Take your first dose when you wake up.
• Avoid late doses — Don't take Zenzedi in the late afternoon or evening, as it can cause insomnia.
• With or without food — You can take it either way, but taking it with food may reduce stomach upset.
• Avoid acidic juices — Acidic fruit juices and Vitamin C can reduce absorption. Don't take your dose with orange juice or grapefruit juice.

Typical Dosage

The usual dose range is 5–40 mg per day, divided into 1–3 doses. For narcolepsy, doses up to 60 mg per day may be used. Your doctor will typically start you on a low dose and gradually increase it based on how you respond and any side effects you experience.

For a full list of side effects and what to watch for, see our guide on Zenzedi side effects.

Who Should Not Take Zenzedi?

Zenzedi is not safe for everyone. You should not take it if you have:

• A known allergy to amphetamines
• Advanced arteriosclerosis (hardening of the arteries)
• Symptomatic cardiovascular disease
• Moderate to severe high blood pressure
• Hyperthyroidism (overactive thyroid)
• Glaucoma
• A history of drug abuse
• An agitated state or severe anxiety
• Current or recent use (within 14 days) of an MAO inhibitor

Before starting Zenzedi, tell your doctor about all your medical conditions, especially any heart problems, mental health conditions, or history of substance use. Also share a complete list of medications you take — drug interactions can be serious with this medication.

How Much Does Zenzedi Cost?

Cost is a major factor for many patients. Here's what to expect in 2026:

• Brand Zenzedi (without insurance): $550–$650 for 60 tablets
• Generic Dextroamphetamine Sulfate (with discount coupon): $30–$80 for 60 tablets
• Generic (retail, no coupon): $150–$400 depending on dose and pharmacy

Insurance Coverage

Generic Dextroamphetamine is covered by most insurance plans as a Tier 2 medication. Brand Zenzedi often requires prior authorization and may not be on your plan's formulary at all. Medicare Part D typically covers generic versions.

Savings Programs

The manufacturer offers a Zenzedi Savings Card through the Arbor E-Z Rx network of 4,000+ independent pharmacies:

• Cash-paying patients: pay no more than $75 per prescription
• Insured patients: first Rx may be free, then $30 per refill
• Savings up to $185 per prescription per month

For more ways to save, including coupon cards, patient assistance programs, and generic alternatives, see our comprehensive guide on how to save money on Zenzedi.

Final Thoughts

Zenzedi is a targeted, effective stimulant for ADHD and narcolepsy. Its active ingredient, Dextroamphetamine, is well-studied and has decades of clinical use behind it. The main challenges in 2026 are availability — due to ongoing stimulant shortages — and cost if you need the brand-name version. Use Medfinder to check pharmacy stock near you, ask your doctor whether generic Dextroamphetamine is an option, and explore savings programs to keep costs manageable.