Dextroamphetamine Is a Prescription Stimulant Used to Treat ADHD and Narcolepsy

Dextroamphetamine is a central nervous system (CNS) stimulant that increases dopamine and norepinephrine in the brain to improve focus, attention, and wakefulness.

If you or someone you care for has been prescribed Dextroamphetamine — or you're researching it before a doctor's appointment — this guide covers everything you need to know: what it is, what it's used for, how to take it, who should avoid it, and how much it costs in 2026.

What Is Dextroamphetamine?

Dextroamphetamine (also called Dextroamphetamine Sulfate) is an amphetamine-class stimulant that has been used in medicine for decades. It is a Schedule II controlled substance under the DEA, meaning it has accepted medical uses but also a high potential for abuse and dependence.

It's available under several brand names:

• Zenzedi — immediate-release tablets (manufactured by Arbor Pharmaceuticals)
• Dexedrine — immediate-release tablets (historically by GlaxoSmithKline)
• Dexedrine Spansule — extended-release capsules
• ProCentra — oral solution (5 mg/5 mL)

Generic Dextroamphetamine is made by multiple manufacturers and is widely available — though the ongoing shortage has made certain strengths and formulations harder to find.

What Is Dextroamphetamine Used For?

Dextroamphetamine is FDA-approved for two conditions:

1. Attention Deficit Hyperactivity Disorder (ADHD)

ADHD is characterized by difficulty paying attention, hyperactivity, and impulsive behavior. Dextroamphetamine helps by increasing the levels of neurotransmitters that support focus and self-regulation. It's prescribed for both children (age 3 and older) and adults.

2. Narcolepsy

Narcolepsy is a sleep disorder that causes excessive daytime sleepiness and sudden sleep attacks. Dextroamphetamine promotes wakefulness and is used when other treatments haven't worked or aren't appropriate.

Off-Label Uses

Some doctors prescribe Dextroamphetamine off-label for treatment-resistant depression and fatigue related to medical conditions. These uses are not FDA-approved and are based on clinical judgment.

How Is Dextroamphetamine Taken?

Dextroamphetamine comes in three formulations:

• Immediate-release (IR) tablets — Available in 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, and 30 mg. Usually taken 1–3 times daily, with the first dose in the morning.
• Extended-release (ER) capsules (Spansule) — Available in 5 mg, 10 mg, and 15 mg. Taken once daily in the morning. Do not crush or chew.
• Oral solution (ProCentra) — 5 mg per 5 mL. Measured with a calibrated device. Useful for patients who can't swallow pills.

Typical dosing:

• ADHD: 5–40 mg per day, starting at 5 mg once or twice daily and increasing by 5 mg each week as needed.
• Narcolepsy: 5–60 mg per day in divided doses.

Your doctor will start you on a low dose and adjust based on how you respond. Take it with or without food. Avoid taking it in the late afternoon or evening, as it can cause insomnia.

Who Should Not Take Dextroamphetamine?

Dextroamphetamine is not appropriate for everyone. You should not take it if you have:

• A known allergy to amphetamines
• Advanced arteriosclerosis (hardening of the arteries)
• Symptomatic cardiovascular disease
• Moderate to severe high blood pressure
• Hyperthyroidism (overactive thyroid)
• Glaucoma
• A history of drug abuse
• Agitated states
• Current or recent use (within 14 days) of an MAO inhibitor

Tell your doctor about all your medical conditions and medications before starting Dextroamphetamine. For a complete list of medications that interact with it, see our drug interactions guide.

How Much Does Dextroamphetamine Cost?

Cost depends on whether you're getting the generic or brand-name version, and whether you have insurance:

• Generic IR tablets: Approximately $37–$45 for a 30-day supply with a coupon (GoodRx, SingleCare)
• Generic ER capsules: $50–$120 per month
• Brand-name Zenzedi: $200–$400+ per month
• With insurance: Generic Dextroamphetamine is covered by most Medicare and commercial plans. Brand versions may require prior authorization.

For more ways to save, check out our complete guide to Dextroamphetamine coupons, discounts, and patient assistance programs.

Final Thoughts

Dextroamphetamine is a well-established, effective medication for ADHD and narcolepsy. It's available in multiple formulations to fit different needs, and generic versions make it relatively affordable. The biggest challenge in 2026 is finding it in stock due to the ongoing shortage.

If you're struggling to fill your prescription, Medfinder can help you find pharmacies near you that have it available. And if you're still exploring your options, our guide to Dextroamphetamine alternatives can help you and your doctor find a backup plan.