Dexedrine (Dextroamphetamine sulfate) is a prescription central nervous system stimulant used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy.

What Is Dexedrine?

Dexedrine is the brand name for Dextroamphetamine sulfate, a CNS stimulant in the amphetamine class. It is the dextro-isomer ("right-handed" version) of amphetamine, which makes it more potent at stimulating the central nervous system than the levo-isomer.

Dexedrine was originally manufactured by SmithKline Beecham and has been available in the U.S. for decades. Today, the brand-name Dexedrine Spansule (extended-release capsule) is manufactured by Amneal Pharmaceuticals. Generic Dextroamphetamine is produced by several companies, including Teva, Mallinckrodt/SpecGx, and Aurobindo.

Key facts:

• Generic name: Dextroamphetamine sulfate
• Drug class: CNS stimulant (amphetamine)
• DEA schedule: Schedule II (CII) — high potential for abuse
• FDA-approved for: ADHD and narcolepsy
• Related brands: Zenzedi (IR tablets), ProCentra (oral solution), Xelstrym (transdermal patch)

What Is Dexedrine Used For?

ADHD (Attention Deficit Hyperactivity Disorder)

Dexedrine is FDA-approved for ADHD in patients ages 3 and older (immediate-release) and ages 6 and older (extended-release Spansule). It helps improve focus, concentration, and impulse control by increasing dopamine and norepinephrine activity in the brain.

Narcolepsy

Dexedrine is also approved for narcolepsy, a sleep disorder that causes excessive daytime sleepiness and sudden sleep attacks. The stimulant effect helps patients stay awake during the day.

Off-Label Uses

Some doctors prescribe Dextroamphetamine off-label for treatment-resistant depression (as an adjunct), excessive daytime sleepiness, and rarely, binge eating disorder. Off-label use should always be discussed with your prescriber.

How Is Dexedrine Taken?

Dexedrine comes in several formulations:

• Dexedrine Spansule (extended-release capsules): 5 mg, 10 mg, and 15 mg. Taken once daily in the morning. Capsules can be swallowed whole or opened and sprinkled on applesauce — but do not crush or chew the beads inside.
• Dextroamphetamine IR tablets (generic): 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, and 30 mg (Zenzedi). Usually taken 1-3 times daily.
• ProCentra (oral solution): 5 mg per 5 mL. Good for patients who have trouble swallowing pills.
• Xelstrym (transdermal patch): 4.5 mg, 9 mg, 13.5 mg, and 18 mg. A newer option applied to the skin.

Typical Dosage

The typical dose range is 5 mg to 60 mg per day, depending on the condition and formulation. Most doctors start with a low dose and increase gradually. For ADHD in adults, a common starting dose is 5-10 mg once or twice daily.

Important tips:

• Take in the morning or early afternoon to avoid insomnia
• Avoid acidic foods and drinks (like orange juice) near your dose — they can reduce absorption
• Don't stop taking Dexedrine suddenly without talking to your doctor
• Schedule II medications require a new prescription each month — no refills

Who Should Not Take Dexedrine?

Dexedrine is not safe for everyone. You should not take it if you have:

• Known allergy to amphetamines or any ingredient in the medication
• Advanced arteriosclerosis (hardening of the arteries)
• Symptomatic cardiovascular disease
• Moderate to severe high blood pressure
• Hyperthyroidism (overactive thyroid)
• Glaucoma
• Agitated states or severe anxiety
• History of drug abuse
• Current use of an MAOI or use of an MAOI within the past 14 days

For a full list of side effects and safety warnings, see our dedicated side effects guide.

How Much Does Dexedrine Cost?

The cost of Dexedrine varies significantly depending on the formulation, dose, and whether you use insurance or pay cash:

• Generic Dextroamphetamine IR tablets: Approximately $20-$60 for 30 tablets with a discount card
• Generic Dextroamphetamine ER capsules: Approximately $38-$120 for 30 capsules with a coupon
• Brand-name Dexedrine Spansule: Can cost up to $685 without insurance

Most insurance plans cover generic Dextroamphetamine. Brand-name Dexedrine Spansule may require prior authorization or step therapy (trying generic first).

If cost is a concern, check out our guide on saving money on Dexedrine with coupons, discount cards, and patient assistance programs.

Final Thoughts

Dexedrine has been a trusted ADHD and narcolepsy treatment for decades. While the ongoing amphetamine shortage has made it harder to find, it remains an effective option for many patients. If you're new to Dexedrine, work closely with your prescriber to find the right dose, and use tools like Medfinder to locate a pharmacy with stock.