Bupropion is an NDRI antidepressant used for depression, SAD, and smoking cessation. Learn about uses, dosage, costs, and what to know in 2026.
Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) prescribed to treat major depressive disorder, seasonal affective disorder, and to help people quit smoking.
It stands apart from most other antidepressants because it doesn't target serotonin — which means it avoids many of the side effects that make other antidepressants difficult to tolerate. Here's everything you need to know about Bupropion in 2026.
Bupropion Hydrochloride is the generic name for a medication sold under several brand names:
It belongs to the aminoketone class of antidepressants and is classified as an NDRI. It was originally developed by GSK and is now manufactured by multiple generic companies including Teva, Par Pharmaceuticals, Lupin, Cipla, and Amneal.
Bupropion is not a controlled substance. It has no DEA scheduling, which means it's easier to prescribe and refill than medications like Adderall or Xanax.
Bupropion is also a component of two combination drugs:
Bupropion comes in three main formulations, each with different dosing schedules:
Important: Swallow SR and XL tablets whole. Do not crush, chew, or split them — this can release the entire dose at once and increase the risk of seizures.
Most people start at 150 mg once daily (XL) or 150 mg once daily (SR), with the dose increased after several days based on response and tolerability. The maximum recommended dose is 450 mg/day.
Take Bupropion at the same time each day. Avoid taking it close to bedtime, as it can cause insomnia. For more on side effects, see our Bupropion side effects guide.
Bupropion is not safe for everyone. You should not take it if you have:
Tell your doctor about all your medical conditions before starting Bupropion. This includes liver disease, kidney disease, high blood pressure, bipolar disorder, and any history of substance use. For a full list of medications to watch for, read our drug interactions guide.
Cost varies widely depending on whether you're getting the brand name or generic:
Generic Bupropion is covered by most Medicare Part D and commercial insurance plans, typically on preferred formulary tiers (Tier 1-2). Brand-name versions may require prior authorization or step therapy.
If cost is a concern, check out our guide on how to save money on Bupropion — including coupons, manufacturer savings programs, and patient assistance programs for uninsured patients.
Bupropion is a versatile, widely prescribed medication that offers real advantages over other antidepressants — particularly its low risk of weight gain and sexual side effects. Whether you're using it for depression, seasonal mood changes, or quitting smoking, understanding how it works and how to take it properly sets you up for the best outcome.
If you have a prescription and need help finding Bupropion in stock, Medfinder shows you real-time availability at pharmacies near you.
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