Acamprosate is an FDA-approved medication for alcohol abstinence. Learn about its uses, dosage, cost, side effects, and what to know in 2026.
Acamprosate (Acamprosate Calcium) is a prescription medication used to help adults maintain abstinence from alcohol after they've stopped drinking. It works by restoring chemical balance in the brain that has been disrupted by long-term alcohol use.
If you or someone you know is working toward recovery from alcohol dependence, here's everything you need to know about Acamprosate in 2026 — from how it works to how much it costs.
Acamprosate is a GABA analogue — a medication structurally similar to a natural brain chemical called gamma-aminobutyric acid (GABA). It was originally sold under the brand name Campral, which has since been discontinued. Today, Acamprosate is available only as a generic, manufactured by companies including Zydus, Teva, Mylan/Viatris, and Amneal.
Key facts about Acamprosate:
Because it is not a controlled substance, Acamprosate can be prescribed by any licensed healthcare provider without special certification. Learn more about finding a prescriber near you.
Acamprosate is FDA-approved for one specific use: helping people with alcohol dependence maintain abstinence after they've stopped drinking. It is meant to be started after you've achieved sobriety — it does not help with acute alcohol withdrawal or detoxification.
Acamprosate works best when combined with counseling, support groups, or a structured recovery program. It is not a cure for alcohol use disorder, but it can significantly reduce cravings and the neurological discomfort that often leads to relapse.
Some providers also use Acamprosate off-label for:
However, these off-label uses are not well-established and should only be considered under a doctor's guidance.
The standard dosage of Acamprosate is:
Important instructions:
For patients with moderate kidney impairment (creatinine clearance 30–50 mL/min), the dose is reduced to one 333 mg tablet three times daily.
Acamprosate is contraindicated in patients with severe kidney impairment (creatinine clearance ≤30 mL/min).
Acamprosate should not be taken by people who have:
Additional precautions:
Since only generic versions are available, Acamprosate is more affordable than many brand-name medications — but the price can still vary significantly:
Acamprosate is covered by most commercial insurance plans, Medicaid, and Medicare Part D. Some Medicaid managed care plans may require prior authorization.
If cost is a barrier, there are several ways to save:
For a complete breakdown, see our guide to saving money on Acamprosate.
Acamprosate has been in an active shortage since 2023. Zydus temporarily discontinued production, and other manufacturers have experienced intermittent supply issues. This means your pharmacy may not always have it in stock.
To check which pharmacies near you currently have Acamprosate available, use Medfinder. You can also read our guide on how to check pharmacy stock without calling.
Acamprosate is a well-established, evidence-based medication that has helped thousands of people maintain sobriety. It's not a controlled substance, it doesn't cause dependence, and it can be prescribed by any licensed healthcare provider.
If you're considering Acamprosate, the first step is talking to your doctor. If you already have a prescription, Medfinder can help you find it in stock near you.
You focus on staying healthy. We'll handle the rest.
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