Phentermine Shortage: What Providers and Prescribers Need to Know in 2026

Updated:

February 27, 2026

Author:

Peter Daggett

Summarize this blog with AI:

A clinical briefing on the Phentermine supply situation in 2026. Understand the shortage drivers, prescribing implications, alternatives, and tools to help your patients.

Provider Briefing: The Phentermine Supply Situation

Phentermine remains the most frequently prescribed anti-obesity medication in the United States. As patient demand for weight-loss pharmacotherapy continues to grow — fueled in part by the GLP-1 receptor agonist boom — providers are increasingly hearing from patients who can't fill their Phentermine prescriptions.

This briefing covers the current supply landscape, regulatory factors, prescribing considerations, and practical tools to help your patients maintain continuity of care.

Timeline: How We Got Here

Phentermine supply concerns didn't emerge overnight. Here's a brief timeline of the contributing factors:

  • 2022-2023: The GLP-1 revolution (semaglutide, tirzepatide) dramatically increased public interest in medical weight management. Phentermine prescriptions rose as an affordable entry point for newly motivated patients.
  • 2023-2024: Intermittent stock-outs began appearing at chain pharmacies, particularly for the 37.5 mg tablet formulation. DEA manufacturing quotas for Schedule IV substances hadn't been adjusted to match the demand surge.
  • 2024-2025: Manufacturers increased production within quota limits. The FDA did not list Phentermine as "in shortage," but pharmacy-level availability remained inconsistent in many regions.
  • 2026 (current): Supply has improved but remains uneven. Patients in high-demand metro areas and those relying on single-source chain pharmacies continue to experience fill delays.

Prescribing Implications

The supply variability has several practical implications for prescribers:

Prescription Transfers and Flexibility

Patients may need to fill prescriptions at pharmacies other than their usual location. Consider these practices:

  • Send prescriptions electronically to give patients flexibility in choosing a pharmacy with stock
  • When feasible, write prescriptions for formulations that may have better availability (e.g., 15 mg capsules vs. 37.5 mg tablets)
  • Discuss alternative strengths proactively — patients on 37.5 mg once daily could potentially be managed with other dosing configurations if their standard formulation is unavailable

Controlled Substance Considerations

As a Schedule IV controlled substance, Phentermine prescriptions carry specific regulatory requirements:

  • Paper prescriptions may limit pharmacy flexibility; e-prescribing allows patients to choose pharmacies with availability
  • State-level PDMP requirements apply — ensure prescriptions are documented appropriately
  • Refill limitations vary by state; counsel patients to plan refills 5-7 days in advance

Duration of Therapy

Phentermine's FDA-approved labeling specifies short-term use (up to 12 weeks). In clinical practice, many obesity medicine specialists prescribe for longer durations based on clinical judgment and patient response. When availability is intermittent, consider whether:

  • A structured treatment course with planned start/stop dates might reduce the impact of supply gaps
  • Transitioning to a longer-term approved medication (Qsymia, Contrave, or a GLP-1 agonist) is clinically appropriate for patients requiring extended pharmacotherapy

Current Availability Picture

As of early 2026, here's what providers should know about Phentermine availability:

  • FDA shortage status: Not currently listed as in shortage
  • Manufacturer supply: Multiple generic manufacturers are actively producing Phentermine (Teva, KVK Tech, Prasco, Lannett, and others)
  • Distributor level: Supply is generally available through major distributors (McKesson, Cardinal Health, AmerisourceBergen) but allocation limits may apply to pharmacies with historically low order volumes
  • Pharmacy level: Availability is inconsistent. Chain pharmacies with automated ordering are more likely to experience stock-outs than independent pharmacies with flexible sourcing
  • Formulation differences: 37.5 mg tablets experience the most stock-outs; 15 mg capsules and 8 mg Lomaira tablets tend to have better availability

Cost and Access Landscape

Phentermine remains remarkably affordable relative to newer anti-obesity medications:

  • Generic Phentermine 37.5 mg #30: $10-$40 with discount card
  • Adipex-P (brand) #30: $50-$75
  • Lomaira 8 mg #90: $40-$80

For comparison:

  • Qsymia: $150-$250/month
  • Contrave: $150-$300/month (generic naltrexone/bupropion may be less)
  • Wegovy: $800-$1,300/month
  • Zepbound: $1,000-$1,500/month

Insurance coverage for Phentermine varies widely. Many commercial plans cover it as a preferred generic, but prior authorization is common. Medicare Part D generally excludes weight-loss medications. Medicaid coverage is state-dependent.

Tools and Resources for Your Practice

Several resources can help you and your patients navigate Phentermine availability:

Medfinder for Providers

Medfinder offers real-time pharmacy stock data that providers and clinical staff can use to direct patients to pharmacies with Phentermine in stock. Consider bookmarking this for your care team.

Patient Education Materials

We've created several patient-facing resources you can share:

Pharmacy Discount Cards

For uninsured or underinsured patients, pharmacy discount cards (GoodRx, SingleCare, RxSaver) can bring generic Phentermine costs to $10-$20/month. These work at most retail pharmacies and require no enrollment.

Looking Ahead

The weight-loss medication market is evolving rapidly. Several trends are worth monitoring:

  • DEA quota adjustments: The DEA periodically reviews and adjusts manufacturing quotas. Increased Phentermine demand may lead to upward revisions that improve supply stability.
  • Expanding telehealth prescribing: More patients are accessing Phentermine through telehealth platforms, which can improve prescription distribution across pharmacies rather than concentrating demand at a few locations.
  • GLP-1 supply stabilization: As GLP-1 manufacturing catches up with demand, some patients who switched to Phentermine as a GLP-1 alternative may transition back, potentially easing Phentermine demand.
  • Oral GLP-1 agents: Oral semaglutide (Rybelsus) and emerging oral formulations may provide additional options for patients who can't find or afford injectable GLP-1 medications.

Final Thoughts

Phentermine availability in 2026 is manageable but requires awareness and planning. The drug isn't in a formal shortage, but pharmacy-level stock-outs continue to disrupt patient care. Providers can help by e-prescribing for flexibility, discussing alternative formulations, proactively planning for supply gaps, and directing patients to tools like Medfinder.

By staying informed about the supply landscape and maintaining open communication with patients about their fill challenges, you can minimize treatment interruptions and keep your patients on track.

Related reading:

Is Phentermine officially in shortage according to the FDA?

No. As of early 2026, Phentermine is not listed on the FDA Drug Shortage database. The supply issues patients and providers are experiencing are best characterized as intermittent, pharmacy-level stock-outs driven by increased demand, DEA manufacturing quotas, and distribution allocation patterns — not a manufacturing-level shortage.

What formulations of Phentermine tend to have better availability?

The 37.5 mg tablet is the most commonly prescribed and experiences the most frequent stock-outs. The 15 mg capsule and Lomaira 8 mg orally disintegrating tablet tend to have better availability. Prescribing alternative strengths when clinically appropriate can help patients avoid fill delays.

Should I transition patients from Phentermine to a longer-term weight-loss medication?

It depends on the clinical scenario. For patients who need ongoing pharmacotherapy beyond 12 weeks, FDA-approved long-term options include Qsymia (phentermine/topiramate), Contrave (naltrexone/bupropion), and GLP-1 agonists (Wegovy, Zepbound). Consider the patient's response to Phentermine, insurance coverage, budget, and availability when deciding.

How can I help patients who can't find Phentermine at their pharmacy?

Direct patients to Medfinder (medfinder.com/providers) to check real-time stock at nearby pharmacies. Consider e-prescribing to allow pharmacy flexibility, writing for alternative strengths that may be more available, and suggesting independent pharmacies that often have more sourcing options than large chains.

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