Learn about common and serious Liraglutide side effects, how to manage nausea, and when to call your doctor. Covers Victoza and Saxenda from FDA labeling.
If you've been prescribed Liraglutide — whether as Victoza for type 2 diabetes or Saxenda for weight management — you probably want to know what side effects to expect. The good news is that most side effects are mild and tend to improve as your body adjusts. But there are some serious warning signs you should know about. This guide covers everything from the most common issues to the rare but important ones, based on FDA labeling.
Liraglutide is a GLP-1 receptor agonist — a class of injectable medications that mimic a natural hormone in your body. It's made by Novo Nordisk (brand) and also available as a generic from Teva and Meitheal Pharmaceuticals. It's taken as a once-daily subcutaneous injection and is used for type 2 diabetes management (as Victoza, 1.2–1.8 mg/day) and chronic weight management (as Saxenda, 3 mg/day). For more details, see our guide on what Liraglutide is and how it's used.
Most people experience some side effects when they first start Liraglutide, especially during the dose titration period. These usually improve within a few weeks:
While uncommon, Liraglutide can cause serious side effects that require immediate medical attention:
Liraglutide carries an FDA boxed warning — the most serious type of warning — about the risk of thyroid C-cell tumors. In animal studies, Liraglutide caused thyroid tumors at doses similar to those used in humans. It's not yet known if this risk applies to people, but the medication is contraindicated if you have:
When to call your doctor: Contact your doctor immediately if you notice a lump or swelling in your neck, difficulty swallowing, hoarseness, or shortness of breath.
Liraglutide has been associated with acute pancreatitis (inflammation of the pancreas). In rare cases, this can become chronic.
When to call your doctor: Seek emergency care if you experience severe, persistent abdominal pain that may radiate to your back, with or without vomiting. Do not restart Liraglutide if pancreatitis is confirmed.
GLP-1 medications, including Liraglutide, are associated with an increased risk of gallstones (cholelithiasis) and gallbladder inflammation (cholecystitis). This risk may be higher in patients who lose weight rapidly.
When to call your doctor: Report sudden pain in the upper right abdomen, especially after eating, fever, or yellowing of the skin or eyes.
Severe nausea, vomiting, or diarrhea can lead to dehydration, which may cause or worsen kidney problems.
When to call your doctor: If you're unable to keep fluids down, notice changes in urination, or experience swelling in your legs or feet, contact your doctor right away.
Liraglutide alone rarely causes low blood sugar. However, the risk increases significantly if you also take Insulin or Sulfonylureas (like Glipizide or Glyburide). Symptoms include shakiness, sweating, confusion, rapid heartbeat, and dizziness.
When to call your doctor: If you experience severe hypoglycemia or lose consciousness, this is a medical emergency.
Rarely, Liraglutide can cause anaphylaxis or angioedema (severe swelling).
When to call your doctor: Seek emergency care for difficulty breathing, severe rash, rapid heartbeat, or swelling of the face, lips, tongue, or throat.
The Saxenda label includes a warning about suicidal behavior and ideation. While a direct link hasn't been confirmed, patients and caregivers should be alert.
When to call your doctor: Report any new or worsening depression, anxiety, mood changes, or thoughts of self-harm.
Liraglutide may cause a small increase in resting heart rate. Your doctor may monitor your heart rate during treatment.
Liraglutide is not recommended during pregnancy. Animal studies showed fetal harm. Saxenda is specifically contraindicated in pregnancy. If you're planning to become pregnant, talk to your doctor about stopping Liraglutide at least two months before conception. Caution is also advised during breastfeeding.
Victoza is approved for children aged 10 and older with type 2 diabetes. Saxenda is approved for adolescents aged 12 and older. Side effects in pediatric patients are generally similar to those in adults.
Liraglutide should be used with caution in patients with kidney or liver impairment. Dehydration from GI side effects can worsen kidney function. Your doctor will monitor your labs more closely.
Most side effects can be managed with simple strategies:
If nausea or vomiting is severe and doesn't improve after 2–3 weeks at the same dose, talk to your doctor. They may slow the titration or consider an alternative medication.
Liraglutide is generally well-tolerated, and most side effects are mild and temporary. The key is to follow the dose titration schedule, stay hydrated, and keep your doctor informed about how you're feeling. If you experience any serious symptoms — especially severe abdominal pain, signs of an allergic reaction, or mood changes — don't wait. Call your doctor or go to the emergency room.
For more information, learn how Liraglutide works or check out Liraglutide drug interactions to make sure your other medications are compatible. Ready to fill your prescription? Use Medfinder to find Liraglutide in stock near you.
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