Ketorolac Drug Interactions You Should Know About

Ketorolac (Toradol) is a powerful NSAID used for short-term acute pain management. Because of its potency and the way it affects your body, it has a long list of drug interactions — some of which are dangerous enough to be outright contraindicated.

Before you start taking Ketorolac, it's essential to understand what medications, supplements, and foods can interact with it. This guide covers the major and moderate interactions, plus what to tell your doctor to stay safe.

How Drug Interactions Work

A drug interaction happens when one substance changes how another substance works in your body. With Ketorolac, interactions typically fall into a few categories:

• Increased bleeding risk — Ketorolac already impairs blood clotting; combining it with other blood-thinning agents amplifies this risk.
• Increased kidney stress — Ketorolac reduces blood flow to the kidneys; other medications that do the same can compound the damage.
• Reduced effectiveness of other drugs — Ketorolac can block the effects of certain blood pressure and heart medications.
• Increased toxicity — Ketorolac can raise blood levels of certain drugs to dangerous concentrations.

Major Drug Interactions (Contraindicated or High Risk)

The following interactions are the most serious. Some are explicitly contraindicated — meaning Ketorolac should never be used with them:

Other NSAIDs

Do not take Ketorolac with any other NSAID, including Ibuprofen (Advil, Motrin), Naproxen (Aleve), Diclofenac (Voltaren), Meloxicam (Mobic), or Celecoxib (Celebrex). Combining NSAIDs dramatically increases the risk of GI bleeding, ulcers, and kidney damage. This is contraindicated.

Aspirin

Aspirin combined with Ketorolac increases both bleeding and GI toxicity risk. This combination is contraindicated, even at low-dose Aspirin used for heart protection. If you take daily Aspirin for cardiovascular prevention, tell your doctor before starting Ketorolac.

Anticoagulants (Blood Thinners)

Warfarin (Coumadin), Heparin, Enoxaparin (Lovenox), Rivaroxaban (Xarelto), Apixaban (Eliquis), and Dabigatran (Pradaxa) all interact with Ketorolac. The combination significantly increases bleeding risk. If you're on a blood thinner, your doctor needs to carefully weigh the risks.

Probenecid

Probenecid (used for gout) increases Ketorolac blood levels by slowing its elimination from the body. This is contraindicated — never take them together.

Pentoxifylline (Trental)

Pentoxifylline, used for circulation problems, increases bleeding risk when combined with Ketorolac. This combination is contraindicated.

Lithium

Ketorolac can significantly increase Lithium blood levels, potentially leading to Lithium toxicity. Symptoms include tremor, nausea, confusion, and in severe cases, seizures. If you take Lithium for bipolar disorder, your doctor needs to monitor your levels closely.

Methotrexate

Ketorolac can increase Methotrexate blood levels, raising the risk of serious toxicity including bone marrow suppression, liver damage, and kidney damage. This is especially dangerous with high-dose Methotrexate used for cancer treatment.

ACE Inhibitors and ARBs

Blood pressure medications like Lisinopril (Zestril), Enalapril (Vasotec), Losartan (Cozaar), and Valsartan (Diovan) can become less effective when combined with Ketorolac. More importantly, the combination increases the risk of acute kidney injury, especially in patients who are dehydrated or elderly.

Diuretics

Water pills like Furosemide (Lasix) and Hydrochlorothiazide (HCTZ) may become less effective with Ketorolac. The combination also stresses the kidneys further.

Cyclosporine

Cyclosporine (Sandimmune, Neoral), used after organ transplants and for autoimmune conditions, combined with Ketorolac increases the risk of kidney damage (nephrotoxicity).

SSRIs and SNRIs

Antidepressants like Fluoxetine (Prozac), Sertraline (Zoloft), Escitalopram (Lexapro), Venlafaxine (Effexor), and Duloxetine (Cymbalta) can increase bleeding risk when combined with Ketorolac, particularly GI bleeding.

Moderate Drug Interactions

Corticosteroids

Prednisone, Dexamethasone, and other corticosteroids combined with Ketorolac increase the risk of GI bleeding and ulcers.

Antiplatelet Agents

Clopidogrel (Plavix), Prasugrel (Effient), and Ticagrelor (Brilinta) combined with Ketorolac increase bleeding risk.

Beta-Blockers

Metoprolol (Lopressor), Atenolol (Tenormin), and other beta-blockers may become less effective at lowering blood pressure when taken with Ketorolac.

Digoxin

Ketorolac may increase Digoxin blood levels, potentially leading to toxicity. Your doctor should monitor Digoxin levels if you need both medications.

Supplements and OTC Products to Watch

Several over-the-counter and herbal products can interact with Ketorolac:

• Fish oil (omega-3 fatty acids) — May increase bleeding risk due to antiplatelet effects.
• Vitamin E (high doses) — Can impair blood clotting.
• Ginkgo biloba — Has blood-thinning properties.
• Garlic supplements — May increase bleeding risk at high doses.
• Turmeric/Curcumin — Has anti-inflammatory and antiplatelet properties.
• OTC pain relievers — Absolutely avoid Ibuprofen, Naproxen, and Aspirin (as discussed above). Acetaminophen (Tylenol) is generally safe to take with Ketorolac.

Food and Drink Interactions

Alcohol

Alcohol significantly increases the risk of GI bleeding and stomach irritation when combined with Ketorolac. Do not drink alcohol while taking this medication, even in small amounts.

High-Fat Meals

A high-fat meal may delay the absorption of oral Ketorolac, meaning it could take longer to start working. However, it doesn't reduce the overall effectiveness. Taking Ketorolac with food can actually help reduce stomach irritation.

What to Tell Your Doctor

Before starting Ketorolac, give your doctor a complete list of everything you take, including:

• All prescription medications (especially blood thinners, blood pressure drugs, Lithium, and Methotrexate)
• Over-the-counter medications (especially any pain relievers)
• Herbal supplements and vitamins
• Whether you drink alcohol and how often

Also tell your doctor about:

• Any history of stomach ulcers, GI bleeding, or kidney problems
• Heart conditions or high blood pressure
• Whether you're pregnant, breastfeeding, or planning to become pregnant
• Any previous allergic reactions to NSAIDs or Aspirin

For a full overview of who should not take this medication, see our article on Ketorolac uses and important safety information.

Final Thoughts

Ketorolac is an effective pain reliever, but its interaction profile is more extensive than many patients realize. The key takeaways: never combine it with other NSAIDs or Aspirin, be extremely cautious with blood thinners, avoid alcohol completely, and always give your doctor a full picture of what you're taking.

Because Ketorolac is only used for up to 5 days, most interactions are manageable with proper awareness and medical supervision. If you have questions about a specific medication, don't guess — ask your pharmacist or prescriber.

Learn more about how Ketorolac works in your body in our mechanism of action guide, or read about side effects to watch for.