Tacrolimus can cost $300+ without insurance. Learn how to save with coupons, discount cards, patient assistance programs, and other strategies.
If you've had an organ transplant, Tacrolimus isn't optional. It's the medication that keeps your body from rejecting your new kidney, liver, or heart. You'll likely take it every single day for the rest of your life. And while the medication itself is life-saving, the cost can be a serious burden — especially if you're uninsured, underinsured, or facing high copays.
The good news? There are real ways to bring down the cost. In this guide, we'll cover exactly how much Tacrolimus costs in 2026, and walk you through every savings option available — from free discount coupons to patient assistance programs that can get you the medication at no cost.
The cost depends on which formulation you take, the dose, and where you fill it. Here's what you can expect to pay without insurance at a retail pharmacy:
Since transplant patients typically need to take Tacrolimus for life, these costs can total thousands of dollars per year even for the generic version — and much more for brand-name formulations.
If you're paying cash or have a high-deductible plan, prescription discount coupons can dramatically reduce your costs. These are free to use and work at most pharmacies nationwide.
How to use them: Simply search for "Tacrolimus" on any of these websites, select your dose and quantity, and compare prices at pharmacies near you. Show the coupon (digital or printed) to your pharmacist when filling your prescription. You don't need insurance to use them.
Important tip: Prices vary significantly between pharmacies — even with the same coupon. Always compare multiple pharmacy locations to find the best deal. Independent pharmacies sometimes offer better coupon prices than chains.
If you're uninsured or have very low income, patient assistance programs can provide Tacrolimus at no cost. These are funded by pharmaceutical manufacturers and nonprofit organizations.
Astellas Pharma (the maker of Prograf and Astagraf XL) runs the Astellas Cares patient assistance program. Eligible patients can receive Prograf or Astagraf XL at no cost. Eligibility is typically based on income and insurance status.
Apply at: astellascares.com
For commercially insured patients taking Astagraf XL, Astellas offers a copay card that reduces your out-of-pocket cost to as little as $0 per fill, with savings up to $3,000 per year. This card is free to enroll in and can be used for up to 12 months.
Note: Copay cards typically cannot be used with Medicare, Medicaid, or other government insurance programs.
If you're currently taking brand-name Prograf, talk to your transplant team about whether generic Tacrolimus IR capsules might be appropriate for you. The generic version can cost $30 to $65 per month with coupons, compared to $570+ for brand-name Prograf. Note: Any switch must be done under medical supervision with blood level monitoring.
Many insurance plans offer lower copays for mail-order prescriptions. Specialty pharmacies that focus on transplant medications may also offer competitive pricing and medication management services. Ask your insurance company about your mail-order options.
If you're on Medicare and have limited income, the Medicare Extra Help (Low-Income Subsidy) program can significantly reduce your Part D prescription costs — including Tacrolimus. Eligible patients pay no more than $4.50 for generic drugs or $11.20 for brand-name drugs per prescription.
Many states offer their own prescription assistance programs (SPAPs) for residents who meet income requirements. Contact your state's health department or visit medicare.gov to see what's available in your area.
Don't assume all pharmacies charge the same price. Use Medfinder to find pharmacies with Tacrolimus in stock, then compare prices using GoodRx or SingleCare. Costco pharmacies (you don't need a membership to use the pharmacy) and Walmart often have competitive pricing on generic medications.
If your insurance allows it, filling a 90-day supply instead of 30-day supply usually costs less per capsule and saves you trips to the pharmacy. This also reduces the risk of running into stockouts.
Envarsus XR, made by Veloxis Pharmaceuticals, also offers a copay assistance program for commercially insured patients. Check with your pharmacy or visit the Envarsus XR website for current offers. As with the Astagraf XL copay card, these programs typically don't apply to government-insured patients.
Tacrolimus is expensive, but no transplant patient should have to skip doses because of cost. Between generic options, free discount coupons, manufacturer copay cards, and patient assistance programs, there are real ways to make this medication affordable.
Here's a quick action plan:
Need help finding Tacrolimus in stock? Use Medfinder to search pharmacy availability near you. And for more about this medication, explore our other guides:
You focus on staying healthy. We'll handle the rest.
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