Save money on Sodium Polystyrene Sulfonate in 2026. Compare prices, find coupons, discount cards, and patient assistance programs for Kayexalate and generic SPS.
If you take Sodium Polystyrene Sulfonate (also known as Kayexalate or SPS) for high potassium, you're probably wondering what it costs and whether you can save money. The good news: this is one of the more affordable prescription medications on the market, especially in its generic powder form. But prices can still vary a lot depending on where you fill your prescription and which form you get.
Here's a complete breakdown of Sodium Polystyrene Sulfonate costs in 2026, plus every way to save.
Sodium Polystyrene Sulfonate is available as a generic, which keeps prices low. Here's what you can expect to pay out of pocket:
The price difference between pharmacies can be significant. A 454 g container of generic powder might cost $8 at one pharmacy and $45 at another — that's a 5x difference for the exact same medication. This is why comparing prices before you fill is so important.
Even though Sodium Polystyrene Sulfonate is already affordable, discount cards can bring the price down even further. These cards are free and work whether or not you have insurance.
How to use a discount card: Search for your medication on any of these sites, select your pharmacy, and show the coupon (on your phone or printed) to the pharmacist when you pick up your prescription. The pharmacy applies the discount at the register — it's that simple.
Important: Discount cards cannot be combined with insurance. If your insurance copay is higher than the discount card price, ask the pharmacist to run the discount card instead. You can always choose the lower price.
Because Sodium Polystyrene Sulfonate is an affordable generic, there are no manufacturer-specific savings programs or copay cards for this medication. However, if you're uninsured or on a limited income, other assistance options exist:
If you have Medicare Part D, generic Sodium Polystyrene Sulfonate is typically covered on Tier 1 or Tier 2, meaning you'll pay a low copay — often $0 to $10. Prior authorization is generally not required for the generic.
Medicaid coverage varies by state but typically covers generic Sodium Polystyrene Sulfonate with little to no cost sharing.
The powder form is almost always cheaper than the pre-mixed suspension. It's also more available due to fewer supply issues. Ask your doctor to prescribe the powder if you're currently on the suspension — it works the same way, you just mix it with water yourself.
Don't assume all pharmacies charge the same price. Use Medfinder to find pharmacies near you that have Sodium Polystyrene Sulfonate in stock, and compare prices using a discount card site. Sometimes the cheapest option is at a pharmacy you haven't tried before.
If you take Sodium Polystyrene Sulfonate regularly, buying a larger container (454 g) is usually more cost-effective per dose than buying smaller quantities. Ask your doctor to write the prescription for the larger size.
Some insurance plans and discount programs offer better pricing on 90-day supplies. If you're taking this medication long-term, a 90-day fill can save you money and reduce trips to the pharmacy.
Mark Cuban's Cost Plus Drugs (costplusdrugs.com) is an online pharmacy that sells many generic medications at transparent, low prices. Check their website to see if they carry Sodium Polystyrene Sulfonate.
If you've been told to switch to Patiromer (Veltassa) or Sodium Zirconium Cyclosilicate (Lokelma) because SPS is unavailable, know that these medications are significantly more expensive:
However, both manufacturers offer savings programs:
If your doctor recommends switching, ask about these programs and check with your insurance first. For a comparison of all alternatives, read: Alternatives to Sodium Polystyrene Sulfonate.
Sodium Polystyrene Sulfonate is one of the most affordable potassium-lowering medications available, with generic powder prices starting under $6 with a coupon. The key to saving money is choosing the generic powder form, comparing prices across pharmacies, and using a free discount card from GoodRx, SingleCare, or another provider.
If you're having trouble finding the medication, Medfinder can help you locate pharmacies with stock near you. And if cost is still a barrier, explore the patient assistance resources listed above or talk to your doctor about the most affordable treatment plan for your situation.
For the latest on availability, read our 2026 Sodium Polystyrene Sulfonate shortage update.
You focus on staying healthy. We'll handle the rest.
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