Prempro 0.625/2.5 28 Day can cost up to $280/month. Learn how to save with coupons, discount cards, generics, and patient assistance programs in 2026.
If you've ever picked up your Prempro 0.625/2.5 28 Day prescription and been shocked by the price, you're not alone. Brand-name Prempro can cost $180 to $280 per month without insurance — a significant expense for a medication you need to take every day.
The good news is that there are several ways to reduce what you pay, whether you have insurance, are uninsured, or are on Medicare. In this guide, we'll break down the actual cost of Prempro in 2026 and walk you through every option for saving money.
Here's what you can expect to pay at the pharmacy counter without any insurance or discounts:
Prices vary significantly by pharmacy. Big chain pharmacies, grocery store pharmacies, and independent pharmacies may all charge different amounts for the same medication. That's why it pays to compare — and to use the discount tools we'll cover below.
With insurance, your copay depends on your plan's formulary. The generic is usually on Tier 1 ($5 to $15 copay) or Tier 2 ($15 to $40 copay). Brand Prempro may be on Tier 2 or Tier 3 ($30 to $60 copay). If your insurance requires the generic, that's actually great news for your wallet.
The single biggest way to save money on Prempro is to use the generic version: Conjugated Estrogens/Medroxyprogesterone Acetate.
The generic contains the exact same active ingredients in the exact same doses as brand-name Prempro. It's FDA-approved as therapeutically equivalent (rated "AB" by the FDA), which means it works the same way in your body.
The price difference is dramatic:
If you're currently paying for the brand, ask your pharmacist about switching to the generic. In most cases, your pharmacist can make this switch automatically unless your doctor has written "dispense as written" on the prescription.
Prescription discount cards are free to use and can significantly reduce your out-of-pocket cost, especially if you're uninsured or if your insurance copay is high. Here are the most popular options:
GoodRx compares prices across pharmacies and offers free coupons. For generic Prempro (Conjugated Estrogens/Medroxyprogesterone Acetate 0.625/2.5 mg), GoodRx coupons can bring the price down to around $35 to $65 per month at participating pharmacies.
SingleCare works similarly to GoodRx and is accepted at most major pharmacies including CVS, Walgreens, and Walmart. Prices for generic Prempro with SingleCare are typically in the $30 to $60 range.
RxSaver by RetailMeNot compares prices across multiple discount programs and shows you the lowest available price at pharmacies near you. It's another useful tool for finding the best deal.
Additional discount programs that may offer savings on Prempro include:
Pro tip: Prices vary by pharmacy, so check multiple pharmacies with your discount card before filling. The difference between the cheapest and most expensive pharmacy can be $30 or more for the same medication.
If you're uninsured, underinsured, or facing financial hardship, patient assistance programs (PAPs) may provide Prempro at little or no cost. These programs are designed for people who truly can't afford their medication.
Since Prempro is manufactured by Pfizer, their patient assistance program — Pfizer RxPathways — is the most direct option. This program offers:
You can apply online at pfizerrxpathways.com or call their helpline. Your doctor's office can also help you apply.
NeedyMeds is a nonprofit that maintains a database of patient assistance programs, discount drug cards, and other resources. Search for Prempro or Conjugated Estrogens on needymeds.org to see all available programs.
RxAssist is another comprehensive database of patient assistance programs. It's particularly useful for finding programs you might not know about, including state-specific programs and charitable organizations.
RxHope connects patients and healthcare providers with pharmaceutical company assistance programs. Your doctor can submit an application on your behalf through rxhope.com.
Don't assume every pharmacy charges the same price. Use Medfinder to find pharmacies with Prempro in stock, and compare prices with a discount card at each location. Costco and Walmart pharmacies often have lower base prices for generic medications.
If you're stable on Prempro, ask your doctor for a 90-day prescription. Many pharmacies and insurance plans offer 90-day supplies at a lower per-month cost than three separate 28-day fills. Mail-order pharmacies frequently offer the best prices for 90-day supplies.
Pfizer occasionally offers manufacturer coupons or savings cards for brand-name Prempro. These are typically available to commercially insured patients (not those on Medicare or Medicaid). Check pfizer.com or ask your pharmacist.
Mail-order pharmacies often have lower prices than retail pharmacies, especially for 90-day supplies. Check with your insurance plan to see if mail-order is available — many plans offer it at a reduced copay. For uninsured patients, online pharmacies like Cost Plus Drugs may offer competitive generic pricing.
Many states offer pharmaceutical assistance programs (SPAPs) for residents who meet certain criteria — often seniors, low-income individuals, or people with disabilities. These programs can supplement Medicare Part D coverage or help uninsured patients. Check with your state's health department for eligibility.
Prempro 0.625/2.5 28 Day doesn't have to break the bank. By switching to the generic, using a free discount card, and exploring patient assistance programs, most patients can significantly reduce their monthly cost — often from over $200 down to $30 to $70 per month.
Here's a quick summary of your best options:
Don't let cost keep you from the menopause treatment you need. And if you're also having trouble finding Prempro in stock, check Medfinder for real-time pharmacy availability near you.
For more information about this medication, see our guides on what Prempro is and Prempro side effects.
You focus on staying healthy. We'll handle the rest.
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