Lupron Depot Is One of the Most Expensive Specialty Drugs — But You Don't Have to Pay Full Price

If you've seen the price tag on Lupron Depot (Leuprolide Acetate), you know it's not cheap. A single injection can cost $2,200 to over $5,500 depending on the dose strength — and many patients need injections every 1 to 6 months for months or years at a time.

The good news: most patients don't pay anywhere near the full cash price. Between insurance coverage, manufacturer programs, and patient assistance, there are real ways to bring your out-of-pocket costs down significantly.

Here's everything you need to know about saving money on Lupron in 2026.

How Much Does Lupron Cost Without Insurance?

Let's start with the reality. Here are approximate cash prices for Lupron Depot in 2026 (without insurance or discounts):

• Lupron Depot 3.75 mg (1-month, endometriosis/fibroids): $2,200–$2,400
• Lupron Depot 7.5 mg (1-month, prostate cancer): ~$2,200
• Lupron Depot 11.25 mg (3-month, endometriosis/fibroids): $3,500–$4,000
• Lupron Depot 22.5 mg (3-month, prostate cancer): $4,500–$5,000
• Lupron Depot 30 mg (4-month, prostate cancer): $4,800–$5,200
• Lupron Depot 45 mg (6-month, prostate cancer): $5,500+

These prices reflect the drug cost alone. Administration fees (the cost of the office visit and injection) add another $50–$200+ depending on your provider and location.

There is no generic equivalent for Lupron Depot's long-acting formulation. While generic Leuprolide Acetate exists as a daily subcutaneous injection (starting around $89 for a 2.8 mL vial), it's a completely different product used in different situations (primarily IVF protocols).

AbbVie's Lupron Depot Savings Card

AbbVie, the manufacturer of Lupron Depot, offers a copay savings card for commercially insured patients. Here's how it works:

• Eligible patients pay as little as $10 per dose
• Maximum savings: $300 per month for a 1-month supply, or $600 per month for a 3-month supply
• Available for patients with commercial (private) insurance only — not valid for Medicare, Medicaid, or other government insurance
• Download and print the card at luprongyn.com/savings-and-support or call 1-855-587-7663

This is one of the most impactful savings options available. If you have private insurance and a Lupron Depot copay, the savings card can potentially reduce your cost to just $10 per injection.

Important: The savings card reduces your copay or coinsurance — the amount you owe after insurance. It does not reduce the total drug cost. You must have insurance that covers Lupron Depot for the card to apply.

myAbbVie Assist: Patient Assistance for Free Lupron

If you're uninsured or underinsured and can't afford Lupron Depot, AbbVie's patient assistance program — myAbbVie Assist — may provide the medication at no cost.

Here's what you need to know:

• Eligibility: Generally for patients with household income under 600% of the Federal Poverty Level (approximately $90,000/year for an individual in 2026)
• Medicare patients: Those under 150% FPL must first apply for and be denied Medicare Extra Help (Low-Income Subsidy) before being evaluated for myAbbVie Assist
• How to apply: Visit abbvie.com/patients/patient-support/patient-assistance or call 1-800-222-6885
• What's provided: Free Lupron Depot medication shipped to your provider's office for administration

The application requires your doctor's involvement, so bring it up at your next appointment. Your provider's office may already be familiar with the process.

Coupons and Discount Cards

Because Lupron Depot is a specialty injectable typically administered in a provider's office (not filled at a retail pharmacy), traditional discount cards from GoodRx, SingleCare, or RxSaver have limited applicability. However, in some cases they can help:

• SingleCare lists a coupon price of approximately $1,850 for Lupron Depot 3.75 mg — a savings of about $500 off the cash price
• GoodRx may show pricing for pharmacies that stock Lupron Depot, though most patients receive it through their provider's buy-and-bill process

These coupons work best if your provider sends the prescription to a specialty pharmacy rather than buying and billing through their office. Ask your doctor if this is an option.

Insurance Coverage Tips

Most insurance plans cover Lupron Depot, but the details matter:

Commercial Insurance

• Lupron Depot is typically covered as a medical benefit (billed under your medical insurance, not pharmacy benefit) when administered in a provider's office
• Prior authorization is almost always required — your doctor's office handles this, but it can take days to weeks
• Some plans require step therapy, meaning you may need to try a different medication first
• Copays and coinsurance vary widely — from $0 to several hundred dollars per injection

Medicare

• Medicare Part B covers Lupron Depot when administered in a doctor's office for approved indications
• You're responsible for the 20% coinsurance after meeting your Part B deductible ($240 in 2024)
• A Medicare Supplement (Medigap) plan can cover this coinsurance
• Remember: AbbVie's copay savings card does not work with Medicare, but myAbbVie Assist may help low-income Medicare patients

Medicaid

• Medicaid typically covers Lupron Depot with minimal or no patient cost
• Prior authorization requirements vary by state

Other Ways to Save on Lupron

Ask About Longer-Interval Dosing

For prostate cancer patients, switching from a 1-month (7.5 mg) to a 3-month (22.5 mg), 4-month (30 mg), or 6-month (45 mg) formulation can save on total administration costs — fewer office visits means fewer copays and administration fees. The drug cost per injection is higher, but the per-month cost may be lower overall.

Consider Alternatives That May Cost Less

Depending on your condition, some alternatives may have lower out-of-pocket costs:

• Orgovyx (for prostate cancer) is an oral medication covered under your pharmacy benefit. Some patients find pharmacy copays more predictable than medical benefit coinsurance.
• Orilissa or Myfembree (for endometriosis/fibroids) are oral options that may be covered differently by your plan.

Learn more about your options in our guide to Lupron alternatives.

Check for State and Nonprofit Assistance

Beyond AbbVie's programs, other organizations may help with medication costs:

• NeedyMeds (needymeds.org) — Database of patient assistance programs and discount programs
• RxAssist (rxassist.org) — Comprehensive directory of patient assistance programs
• PAN Foundation and HealthWell Foundation — May offer copay assistance for cancer patients
• CancerCare — Financial assistance for cancer treatment costs

Talk to Your Doctor's Billing Office

Your provider's billing department may be able to help you:

• Verify your insurance coverage and expected out-of-pocket cost before your injection
• Apply the AbbVie savings card or patient assistance
• Appeal a denied prior authorization
• Set up a payment plan if needed

Final Thoughts

Lupron Depot is expensive, but most patients have access to programs that can significantly reduce what they pay. Here's a quick action plan:

1. If you have commercial insurance: Get the AbbVie savings card — you could pay as little as $10/dose
2. If you're uninsured or underinsured: Apply for myAbbVie Assist for free medication
3. If you have Medicare: Check if you qualify for myAbbVie Assist or Medicare Extra Help
4. For everyone: Ask your doctor about longer dosing intervals and whether a lower-cost alternative might work

Don't let cost prevent you from getting the treatment you need. And if you're also struggling to find Lupron in stock, Medfinder can help you locate it near you.

For more information about Lupron, read our guides on what is Lupron, Lupron side effects, and the 2026 shortage update.