Dificid can cost over $5,000 without insurance. Learn how to save with coupons, discount cards, generic options, and patient assistance programs in 2026.
Dificid (Fidaxomicin) is one of the most effective treatments for C. difficile infections — but it's also one of the most expensive antibiotics you can be prescribed. If you've seen the price tag and felt your stomach drop, you're not alone.
The good news? There are real ways to bring the cost down significantly. In this guide, we'll break down exactly what Dificid costs in 2026, walk through every savings option available, and help you find the best deal for your situation.
Let's start with the numbers. A standard course of Dificid is 20 tablets (200 mg each), taken twice daily for 10 days.
Yes, you read that right — even a short course of this antibiotic can cost thousands of dollars at full price. That's why it's critical to use every savings tool available to you.
The single biggest way to save money on Dificid is to fill the generic version. Teva launched generic Fidaxomicin tablets in July 2025. It's AB-rated by the FDA, meaning it's therapeutically equivalent to brand-name Dificid — same active ingredient, same dose, same effectiveness.
When you add a discount coupon on top of the generic, the savings are substantial:
That's a savings of roughly $3,800 to $5,200 per course by switching to the generic with a coupon.
Ask your doctor to prescribe "Fidaxomicin" (generic) rather than "Dificid" (brand), and make sure the prescription doesn't say "Dispense as Written" — that would prevent the pharmacist from substituting the generic.
Merck, the maker of brand-name Dificid, offers a savings coupon for commercially insured patients:
You can find the coupon at your prescriber's office or search online for the Merck Dificid savings offer.
Teva offers its own savings card for the generic:
If you have commercial insurance and are filling the generic, the Teva copay card may bring your out-of-pocket cost down to just $50.
If you don't have insurance — or if your insurance copay is higher than the coupon price — prescription discount cards can provide significant savings on generic Fidaxomicin:
These cards are free to use and don't require insurance. Simply show the coupon at the pharmacy when you fill your prescription. Prices vary by pharmacy, so it's worth checking multiple locations.
Pro tip: Independent pharmacies sometimes offer better pricing with discount cards than large chains. Use Medfinder to find pharmacies near you that stock Fidaxomicin, then compare discount card prices at each location.
If you're uninsured or can't afford your medication even with coupons, patient assistance programs (PAPs) may provide Dificid for free or at very low cost.
Merck's program at merckhelps.com provides Dificid free of charge to eligible individuals:
The PAN Foundation may provide copay assistance for patients with insurance who still face high out-of-pocket costs. Check their website for current fund availability and eligibility.
These nonprofit databases can help you find additional assistance programs:
If you're being discharged from the hospital after a C. diff infection, ask if the hospital's outpatient pharmacy can fill your Fidaxomicin prescription. Hospital pharmacies sometimes have negotiated pricing that's lower than retail, and you'll get the medication immediately rather than having to search for a stocking pharmacy.
Fidaxomicin pricing varies significantly from pharmacy to pharmacy. Some independent pharmacies may offer better pricing than chains, especially when combined with discount coupons. It's worth spending a few minutes comparing prices before you fill.
If you have insurance, check which tier Dificid or Fidaxomicin falls on your plan's formulary:
If it's on a high tier, the manufacturer copay card or Teva savings card may still bring your cost down to $50.
If cost is simply prohibitive even with all available assistance, talk to your doctor. Oral Vancomycin is the other first-line treatment for C. diff and costs $300–$600 for a 10-day course — or even less with discount coupons. Metronidazole is another option at under $20, though it's no longer considered first-line. Read our full comparison: Alternatives to Dificid.
Dificid is an expensive medication, but you shouldn't have to choose between your health and your finances. Between generic substitution, manufacturer coupons, discount cards, and patient assistance programs, most patients can bring the cost down to a manageable level.
Start by asking your pharmacist about generic Fidaxomicin and checking discount card prices on GoodRx or SingleCare. If you're commercially insured, the Merck or Teva copay cards can reduce your cost to as little as $50. And if you're uninsured, the Merck Patient Assistance Program may provide the medication for free.
Need help finding a pharmacy that has Dificid in stock? Use Medfinder to search real-time availability near you.
You focus on staying healthy. We'll handle the rest.
Try Medfinder Concierge FreeMedfinder's mission is to ensure every patient gets access to the medications they need. We believe this begins with trustworthy information. Our core values guide everything we do, including the standards that shape the accuracy, transparency, and quality of our content. We’re committed to delivering information that’s evidence-based, regularly updated, and easy to understand. For more details on our editorial process, see here.
%2C%20Color%3DOriginal.png)
