How to Help Your Patients Find Isentress in Stock: A Provider's Guide

As a prescriber, you know that uninterrupted access to antiretroviral therapy is critical for HIV treatment success. When patients can't fill their Isentress (Raltegravir) prescriptions, it's not just an inconvenience — it's a direct threat to viral suppression, adherence, and long-term outcomes.

This guide provides practical, actionable steps your clinical team can take to help patients find Isentress in stock and maintain continuity of care.

Current Isentress Availability

Isentress is not in an official drug shortage as of early 2026. It is not listed on the FDA or ASHP drug shortage databases. However, availability at the pharmacy level is inconsistent for several reasons:

• High retail cost: At $1,900–$2,500/month, many retail pharmacies don't maintain routine Isentress inventory
• Specialty medication status: Isentress is often classified as a specialty drug by insurers, directing patients to specific specialty pharmacies
• No widely available generic: Despite Lupin's FDA approval for generic Raltegravir in May 2025, the generic has not achieved widespread pharmacy distribution
• Prior authorization requirements: Some plans require PA for Isentress, especially for new starts, given guideline preference for Dolutegravir and Bictegravir

Why Patients Can't Find Isentress

Understanding the root causes helps your team intervene effectively:

Pharmacy Stocking Decisions

Pharmacies make stocking decisions based on demand. A pharmacy that fills one Isentress prescription per month may not keep it in regular inventory, opting instead to order it when needed. This creates a 1–3 day delay that patients may interpret as a shortage.

Wholesaler Allocation

Drug wholesalers may allocate limited quantities of specialty medications to individual pharmacies based on historical ordering patterns. A pharmacy that hasn't previously ordered Isentress may face longer lead times or order limits.

Insurance Channel Restrictions

Many commercial insurance plans and pharmacy benefit managers (PBMs) require HIV medications to be filled through designated specialty pharmacies. If the patient's plan mandates a specific dispensing channel, their local retail pharmacy cannot fill the prescription even if they have stock.

What Providers Can Do: 5 Actionable Steps

Step 1: Verify Pharmacy Availability Before the Patient Leaves

Don't assume the patient's pharmacy has Isentress. Before they leave your clinic:

• Ask which pharmacy they use
• Call the pharmacy to confirm stock or the ability to order within 24–48 hours
• If unavailable, use Medfinder for Providers to identify a nearby pharmacy with real-time Isentress inventory

Step 2: Build Relationships with Specialty Pharmacies

Establish referral pathways with 1–2 specialty pharmacies in your area that reliably stock HIV medications. Many HIV clinics have formal partnerships with specialty pharmacies or operate on-site 340B pharmacies. These pharmacies:

• Maintain consistent INSTI inventory
• Provide adherence monitoring and counseling
• Coordinate directly with insurance for prior authorizations
• Offer delivery services to patients

Step 3: Proactively Manage Prior Authorizations

If your patient's insurance requires prior authorization for Isentress:

• Submit the PA at the time of prescribing, not after the patient arrives at the pharmacy
• Document the clinical rationale clearly — especially for patients where Isentress is specifically indicated (pregnancy, neonatal exposure, drug interaction concerns)
• Have your team follow up within 24–48 hours to confirm approval
• Keep PA appeal templates on file for common denial scenarios

Step 4: Enroll Patients in Merck's SUPPORT Program

Merck offers comprehensive patient support through several programs:

• Copay savings card: Up to $6,800/year for commercially insured patients
• Patient Assistance Program: Free medication for eligible uninsured patients (merckhelps.com)
• SUPPORT Program: Insurance navigation, pharmacy location assistance, and coverage support

Initiating enrollment during the clinic visit — rather than leaving it to the patient — significantly improves utilization rates.

Step 5: Have a Switching Protocol Ready

For patients with persistent access issues, have a documented switching protocol based on current DHHS guidelines:

• First choice: Dolutegravir (Tivicay) — widely available, generic options, high resistance barrier
• Single-tablet option: Biktarvy (Bictegravir/Emtricitabine/TAF) — simplifies the regimen to one pill daily
• Injectable option: Cabenuva (Cabotegravir + Rilpivirine) — for virologically suppressed patients who prefer monthly or every-two-month injections

Before switching, ensure: current viral load is documented, resistance testing is reviewed, concomitant medications are checked for interactions, and the patient is counseled on the new regimen.

For a detailed comparison of alternatives, see our clinical overview of alternatives to Isentress.

Workflow Tips for Your Clinical Team

Create a Medication Access Checklist

Develop a standard workflow for all patients on specialty HIV medications:

1. Confirm pharmacy and insurance details at every visit
2. Check for upcoming prior authorization renewals
3. Verify the pharmacy can fill the prescription before the patient leaves
4. Provide the patient with Medfinder information as a backup resource
5. Document any access barriers in the chart for follow-up

Designate a Medication Access Coordinator

If your practice volume supports it, designate a team member (nurse, social worker, or pharmacy technician) as the medication access point person. This individual can:

• Track prior authorization statuses
• Coordinate with specialty pharmacies
• Enroll patients in manufacturer assistance programs
• Follow up on patients who report fill difficulties

Use Medfinder for Providers

Medfinder for Providers is a real-time pharmacy inventory tool that your clinical team can use to locate Isentress and other medications at nearby pharmacies. Bookmark it as part of your standard prescribing workflow.

Alternatives to Consider

When switching is clinically appropriate, the following alternatives are well-supported:

• Dolutegravir (Tivicay): 50 mg once daily. Preferred INSTI per DHHS. Generic available. Also in combination as Triumeq, Dovato, and Juluca
• Biktarvy: Complete single-tablet regimen. One pill once daily. High resistance barrier. Widely stocked at retail pharmacies
• Cabenuva: Long-acting injectable. Monthly or every-two-month administration. Eliminates daily pill burden. Requires clinic or home injection
• Genvoya/Stribild: Elvitegravir-based single-tablet regimens. Less preferred due to lower resistance barrier and boosting requirement, but may be appropriate for select patients

Final Thoughts

Access barriers to Isentress are real, even in the absence of an official shortage. Providers who proactively address pharmacy availability, insurance navigation, and cost assistance can prevent treatment interruptions that compromise patient outcomes.

Integrate tools like Medfinder for Providers into your clinical workflow, build specialty pharmacy relationships, and ensure your team is equipped to handle access issues before they become adherence crises.

For additional provider resources, see our articles on the Isentress shortage briefing for providers and helping patients save money on Isentress.