Helping Your Patients Find Baloxavir Marboxil: A Practical Guide for Providers

When you prescribe Baloxavir Marboxil (Xofluza) for influenza treatment or post-exposure prophylaxis, the last thing you want is for your patient to encounter a pharmacy stock-out. Yet during the 2025-2026 flu season, many providers have reported that their patients are struggling to fill Xofluza prescriptions. This guide provides actionable steps to integrate into your clinical workflow to help ensure your patients get treated within the critical 48-hour window.

Understanding the Problem

Baloxavir Marboxil faces unique availability challenges as a single-source branded product with no generic equivalent. During peak flu season, pharmacy-level inventory can be depleted rapidly, particularly in high-demand regions. While Genentech continues to manufacture and distribute Xofluza, the mismatch between surge demand and available pharmacy stock creates practical access barriers for patients.

For a detailed analysis of current supply factors, see our Baloxavir Marboxil shortage update for providers.

Step 1: Check Availability Before Prescribing

The most impactful step you can take is verifying pharmacy availability before or at the time of prescribing. This prevents patients from spending valuable treatment-window time searching for a pharmacy with stock.

• Use MedFinder for Providers: This tool allows you to search real-time pharmacy availability for Baloxavir Marboxil by location. You can share results directly with patients or use them to guide e-prescribing decisions.
• Check the Xofluza product finder: Available at xofluza.com, this manufacturer-provided tool shows pharmacies with likely availability based on zip code, including options for same-day delivery.
• Contact preferred pharmacies directly: If your practice has established relationships with local pharmacies, a quick phone call or electronic inquiry can confirm stock before the prescription is sent.

Step 2: Optimize Your Prescribing Workflow

Integrating availability checks into your prescribing workflow does not need to be time-consuming. Consider these approaches:

• Designate a team member (nurse, medical assistant, or pharmacy liaison) to check Xofluza availability while you complete the patient encounter.
• Route e-prescriptions strategically. Send prescriptions to pharmacies that have confirmed stock rather than defaulting to the patient's usual pharmacy.
• Use backup prescriptions. Provide a secondary prescription for Oseltamivir with clear instructions: "Fill whichever medication is available first. Do not fill both." This ensures the patient can start treatment without needing to call your office again.
• Document the strategy. Note in the patient record that a backup prescription was provided and why, to avoid confusion on follow-up.

Step 3: Direct Patients to Availability Resources

Empower patients to participate in finding their medication by sharing these resources:

• MedFinder: Free pharmacy search tool for patients to find medications in stock near them.
• Xofluza product finder (xofluza.com): Manufacturer-provided pharmacy locator with availability data.
• Patient-facing guides: Share links to articles like how to find Baloxavir Marboxil in stock and how to check if a pharmacy has Baloxavir Marboxil.

Consider creating a printed handout or digital resource with these links that front desk staff can provide to patients leaving with a Xofluza prescription.

Step 4: Address Cost Barriers Proactively

Availability is only part of the equation. Cost can also prevent patients from filling their prescriptions, particularly for uninsured or underinsured patients. Xofluza's cash price ranges from $200 to $250, which can be prohibitive.

Provider resources for managing cost barriers:

• Xofluza coupon: Commercially insured patients may pay as little as $35 (up to $70 off out-of-pocket cost). Available at xofluza.com.
• $50 Cash Pay Option: Eligible self-pay patients can pay $50 at select pharmacies.
• Genentech Patient Foundation: Free medication for eligible uninsured/underinsured patients.
• Genentech Access Solutions: Insurance navigation and appeals assistance (1-866-422-2377).

For a comprehensive overview, see our guide on helping patients save money on Baloxavir Marboxil. For patient-facing cost information, share how to save money on Baloxavir Marboxil.

Step 5: Have Alternative Plans Ready

Despite best efforts, there will be situations where Xofluza simply cannot be located in time. Having a seamless alternative prescribing plan ensures continuity of care:

• Oseltamivir (generic Tamiflu): 75 mg PO BID × 5 days. Widely available and affordable. First-line alternative for most patients.
• Zanamivir (Relenza): 10 mg inhaled BID × 5 days. Avoid in patients with reactive airway disease.
• Peramivir (Rapivab): Single IV dose. Consider for hospitalized patients or those unable to tolerate oral medications.

For patient-facing information on alternatives, direct patients to alternatives to Baloxavir Marboxil.

Step 6: Establish Pharmacy Partnerships

Building proactive relationships with local pharmacies during flu season can provide significant advantages:

• Ask pharmacy partners to alert your practice when Xofluza stock is running low.
• Coordinate with pharmacies to reserve or prioritize Xofluza for your patients when possible.
• Work with pharmacy buyers to understand restocking timelines so you can set patient expectations.

Workflow Summary

Here is a quick-reference workflow for managing Xofluza prescriptions during shortage conditions:

1. Diagnose influenza and determine Xofluza is appropriate
2. Check availability via MedFinder or pharmacy contact
3. E-prescribe to a pharmacy with confirmed stock
4. Provide backup Oseltamivir prescription if availability is uncertain
5. Share patient resources (MedFinder, savings programs)
6. Document prescribing strategy in the patient record

Summary

The Baloxavir Marboxil shortage requires providers to be proactive about availability verification, strategic prescribing, and patient education. By integrating availability checks into your workflow, leveraging tools like MedFinder for Providers, and having clear alternative plans, you can help ensure your patients receive timely influenza treatment even during supply disruptions. The 48-hour treatment window leaves no room for delays—preparation is key.