Finding a Doctor Who Can Prescribe Revumenib

If you or a loved one has been diagnosed with acute leukemia involving a KMT2A translocation or NPM1 mutation, your doctor may have mentioned Revumenib (brand name Revuforj). But not every doctor can prescribe this medication. Revumenib is a specialty oncology drug that requires specific expertise and testing before it can be started.

This guide walks you through exactly how to find the right provider, what to expect at your appointment, and how to move forward once you have your prescription.

What Type of Doctor Prescribes Revumenib?

Revumenib is not something your primary care doctor or a general practitioner will prescribe. Because it treats a very specific type of leukemia, you need a specialist. The doctors who typically prescribe Revumenib include:

• Hematologists — doctors who specialize in blood disorders
• Oncologists — doctors who specialize in cancer treatment
• Hematologist-Oncologists — specialists who focus specifically on blood cancers like leukemia
• Pediatric Oncologists — for patients aged 1 year and older who need Revumenib

These specialists work at cancer centers, academic medical centers, and large hospital systems. They have access to the genetic testing needed to confirm your leukemia has a KMT2A translocation or NPM1 mutation — which is required before Revumenib can be prescribed.

How to Find a Provider

There are several ways to find a qualified specialist near you. Here are the most effective approaches:

1. Ask Your Current Doctor for a Referral

If you already have a diagnosis of acute leukemia, your current oncologist or hematologist may be able to prescribe Revumenib directly. If they are not familiar with menin inhibitors like Revumenib, ask them to refer you to a specialist who is. Academic medical centers and NCI-designated cancer centers are most likely to have experience with this medication.

2. Use Your Insurance Provider Directory

Log into your health insurance company's website and search for in-network hematologists or oncologists. This is one of the fastest ways to find a covered provider near you. Look for doctors affiliated with major cancer centers, as they are more likely to be experienced with newer targeted therapies like Revumenib.

3. Search on Zocdoc or Healthgrades

Websites like Zocdoc, Healthgrades, and Vitals let you search for hematologist-oncologists by location and insurance. While these platforms may not specifically list "Revumenib prescriber," you can filter for hematology-oncology specialists in your area and then call to confirm they have experience with menin inhibitors.

4. Contact NCI-Designated Cancer Centers

The National Cancer Institute (NCI) designates certain cancer centers as leaders in cancer research and treatment. These centers are among the first to adopt new therapies. You can search for an NCI-designated cancer center near you at cancer.gov. Many of these centers have leukemia-specific programs where doctors are very familiar with Revumenib.

5. Call SyndAccess for Help

The manufacturer of Revumenib, Syndax Pharmaceuticals, runs a patient support program called SyndAccess. They can help connect you with a prescriber and navigate insurance. Call 1-888-567-SYND (7963), Monday through Friday, 8 AM to 8 PM ET.

6. Consider Telehealth for Initial Consultations

While Revumenib itself requires in-person monitoring (including ECG tests and blood work), some hematologist-oncologists offer telehealth consultations for initial evaluations. This can be helpful if you live in a rural area and want to discuss your options before traveling to a specialist. Keep in mind that ongoing treatment will require in-person visits for cardiac monitoring.

What to Expect at Your Appointment

Once you find a specialist, here is what typically happens before Revumenib is prescribed:

1. Genetic testing confirmation — Your doctor will verify that your leukemia has a KMT2A translocation or susceptible NPM1 mutation through molecular testing. This is required for Revumenib to be appropriate.
2. Cardiac evaluation — Revumenib carries a boxed warning for QTc prolongation. Your doctor will perform an ECG before starting treatment. Patients with a QTcF interval greater than 450 milliseconds cannot start the drug.
3. Blood work — Your white blood cell count must be below 25 Gi/L before treatment begins. Your doctor will also check liver function, electrolytes, and other standard labs.
4. Treatment plan discussion — Your doctor will explain the dosing (typically 270 mg twice daily for adults weighing 40 kg or more), potential side effects, and monitoring schedule.
5. Prior authorization — Your doctor's office will work with your insurance to get Revumenib approved. This may take several days to a few weeks.

After You Get Your Prescription

Once your doctor writes the prescription, the process is a bit different from picking up a typical medication at your local pharmacy. Here is what to know:

Specialty Pharmacy Dispensing

Revumenib is dispensed exclusively through specialty pharmacies. Your doctor's office will coordinate with the specialty pharmacy, and the medication will typically be shipped directly to you or to your doctor's office. You will not find Revumenib at your local CVS or Walgreens.

If you are having trouble locating Revumenib at a specialty pharmacy, check our guide on finding Revumenib in stock or use Medfinder to search pharmacy availability near you.

Cost and Financial Assistance

Revumenib has a wholesale acquisition cost of approximately $39,500 per month — about $474,000 per year. That is a significant number, but most patients do not pay anywhere near that amount. Here is why:

• Commercial insurance: The Revuforj Copay Program through SyndAccess may cover your out-of-pocket costs, potentially bringing your copay to $0.
• Patient assistance: If you are uninsured or underinsured, SyndAccess offers financial assistance programs. Call 1-888-567-SYND (7963).
• Prior authorization: Most commercial plans cover Revumenib with prior authorization, given its orphan drug status and the limited patient population.

For more details on saving money, read our full guide on Revumenib coupons, discounts, and patient assistance.

Ongoing Monitoring

After starting Revumenib, you will need regular follow-up appointments. Expect:

• Weekly ECGs for the first 4 weeks, then monthly
• Regular blood work to monitor liver function and blood counts
• Monitoring for signs of differentiation syndrome, a potentially serious but treatable complication

Final Thoughts

Finding the right doctor to prescribe Revumenib takes a few extra steps compared to most medications, but the process is manageable. Start with your current care team, look into academic cancer centers or NCI-designated facilities, and do not hesitate to call SyndAccess for help navigating the process.

If you already have a prescription and need help finding Revumenib in stock, use Medfinder to search pharmacy availability near you.