Flovent Drug Interactions: What You Need to Know

Flovent (Fluticasone Propionate) is an inhaled corticosteroid that works primarily in the lungs. Because it's inhaled rather than swallowed, most of the drug stays local — but some does enter your bloodstream. Certain medications can interfere with how your body processes that absorbed Fluticasone, potentially turning a safe inhaled dose into something that causes bodywide side effects. Here's what to watch for.

How Drug Interactions Work with Flovent

Fluticasone Propionate is broken down in the body by a liver enzyme called CYP3A4. This enzyme normally processes the small amount of Fluticasone that enters your bloodstream and clears it out quickly.

The problem: if you take another medication that blocks CYP3A4, your body can't clear Fluticasone efficiently. The drug accumulates in your system, and what was a safe inhaled dose starts acting more like an oral corticosteroid — causing systemic effects like adrenal suppression, Cushing's syndrome, and bone density loss.

This is the primary mechanism behind nearly all significant Flovent drug interactions.

Medications That Interact with Flovent

Major Interactions (Avoid if Possible)

These medications are strong CYP3A4 inhibitors and can dramatically increase your systemic exposure to Fluticasone. Combining them with Flovent has caused documented cases of Cushing's syndrome and adrenal suppression:

• Ritonavir (Norvir) — An HIV protease inhibitor and the most well-documented interacting drug. The FDA labeling specifically warns against this combination. Ritonavir can increase Fluticasone exposure by up to 350-fold.
• Cobicistat (Tybost) — Another HIV medication used as a pharmacokinetic booster. Same mechanism as Ritonavir.
• Ketoconazole (Nizoral) — An antifungal medication. Oral Ketoconazole significantly inhibits CYP3A4. Topical Ketoconazole (shampoo, cream) is less concerning.
• Itraconazole (Sporanox) — Another oral antifungal with strong CYP3A4 inhibition.
• Clarithromycin (Biaxin) — A macrolide antibiotic commonly prescribed for respiratory infections. If you need an antibiotic while on Flovent, your doctor may choose Azithromycin (Zithromax) instead, which has weaker CYP3A4 effects.

If you take any of these medications and need an inhaled corticosteroid, talk to your doctor. They may switch you to Beclomethasone (QVAR), which is not metabolized by CYP3A4 and is generally considered safer in this situation. See our alternatives guide for options.

Moderate Interactions (Use with Caution)

These are moderate CYP3A4 inhibitors. They increase Fluticasone exposure less dramatically than the major inhibitors but still warrant monitoring:

• Erythromycin (E-Mycin, Ery-Tab) — A macrolide antibiotic
• Diltiazem (Cardizem) — A calcium channel blocker for high blood pressure and heart conditions
• Verapamil (Calan, Verelan) — Another calcium channel blocker
• Fluconazole (Diflucan) — An antifungal commonly prescribed for yeast infections

If you take one of these medications regularly, your doctor should use the lowest effective dose of Flovent and monitor for signs of excess corticosteroid effects like unusual fatigue, weight gain, or easy bruising.

Other Corticosteroids

Using Flovent alongside other corticosteroids — whether oral (Prednisone, Methylprednisolone), other inhaled steroids, nasal steroids (Flonase, which is also Fluticasone), or topical steroids — can lead to additive corticosteroid effects. This increases the risk of adrenal suppression and other systemic side effects. If you use Flonase nasal spray and a Fluticasone inhaler, your total Fluticasone exposure is higher than either alone.

Supplements and Over-the-Counter Medications to Watch

Most OTC medications don't significantly interact with Flovent, but a few deserve mention:

• St. John's Wort — This herbal supplement is a CYP3A4 inducer (the opposite of an inhibitor). It may slightly reduce Flovent's effectiveness, though this is more relevant for oral medications.
• Antifungal creams/lozenges — If you develop oral thrush from Flovent (a common side effect), your doctor may prescribe Nystatin mouth rinse, which doesn't interact with Flovent. However, if oral Fluconazole is prescribed, be aware of the moderate CYP3A4 interaction noted above.

MAO inhibitors and tricyclic antidepressants have a theoretical interaction listed in some references, but this is not considered clinically significant at standard inhaled doses.

Food and Drink Interactions

Grapefruit juice is a mild CYP3A4 inhibitor and may slightly increase systemic Fluticasone exposure. For most people taking standard doses, this isn't a major concern. However, if you drink large quantities of grapefruit juice daily and use higher doses of Flovent, it's worth mentioning to your doctor.

There are no other significant food interactions with Flovent. You don't need to take it with or without food — it's inhaled, so meals don't affect absorption.

What to Tell Your Doctor

Before starting Flovent or any time your medications change, make sure your doctor and pharmacist know about:

• All prescription medications — especially HIV medications, antifungals, antibiotics, blood pressure medications, and any oral or inhaled steroids
• Over-the-counter medications — including nasal sprays like Flonase (which also contains Fluticasone)
• Herbal supplements — especially St. John's Wort
• Your complete medical history — liver disease can affect how your body processes Fluticasone

Don't stop taking any medication without talking to your doctor first. If a significant interaction is identified, your doctor can adjust doses, switch medications, or increase monitoring — but abruptly stopping either drug can be harmful.

Final Thoughts

Flovent is generally safe when used as directed, and most patients won't experience significant drug interactions. The main concern is strong CYP3A4 inhibitors — particularly Ritonavir, Ketoconazole, and Clarithromycin — which can cause Fluticasone to accumulate in your body. If you take any of these, talk to your doctor about alternatives.

For more on managing your Flovent prescription, visit Medfinder to find pharmacies with the authorized generic Fluticasone Propionate inhaler in stock, or explore our guides on what Flovent is and how to save money on it.