Learn about Daytrana side effects, from common skin irritation to serious reactions. Know what to watch for and when to contact your doctor.
Daytrana (methylphenidate transdermal system) is a prescription patch used to treat ADHD in children aged 6-17. Like all medications, it comes with potential side effects. Whether you're currently using Daytrana or considering it as a treatment option, understanding what to expect can help you make informed decisions and know when to seek medical attention.
This guide covers the most common and serious side effects, what to watch for in specific populations, and practical tips for managing them.
Daytrana is a methylphenidate transdermal patch that delivers ADHD medication through the skin over a 9-hour period. It works by blocking the reuptake of dopamine and norepinephrine in the brain, which helps improve focus, attention, and impulse control.
For a comprehensive overview, see our guide on what Daytrana is, its uses, and dosage information.
Important note: Daytrana has been discontinued by its manufacturer, Noven Pharmaceuticals. This information remains relevant for patients who may still have a supply or are researching alternatives. For current options, see our guide to Daytrana alternatives.
The following side effects are relatively common with Daytrana. Most are mild and may improve over time as the body adjusts to the medication.
This is the most common side effect unique to Daytrana. Because the medication is delivered through a patch, redness, itching, and irritation at the application site are very common. Alternating hips daily can help reduce irritation. In clinical trials, application site reactions occurred in up to 35-45% of patients.
Like other stimulant medications, Daytrana commonly causes decreased appetite. This can lead to weight loss, which is particularly concerning in growing children. Monitoring your child's weight and growth at regular checkups is important.
Gastrointestinal discomfort, including nausea and abdominal pain, is a frequently reported side effect. These symptoms often improve after the first few weeks of treatment.
Difficulty falling asleep is common with stimulant medications. With Daytrana, removing the patch earlier in the day can help, since the medication's effect is partially controlled by how long the patch is worn.
Some patients experience mood swings, irritability, or emotional sensitivity while on Daytrana. These effects are typically mild but should be monitored and reported to your doctor.
Daytrana may cause or worsen motor tics (involuntary movements) or vocal tics in some children. If tics develop, inform your doctor promptly.
While less common, the following side effects require immediate medical attention:
This is a unique and potentially permanent side effect of Daytrana. Chemical leukoderma causes loss of skin color (depigmentation) at and around the application site. Unlike regular skin irritation, this condition may not be reversible. If you notice areas of skin that appear lighter or have lost color, contact your doctor immediately.
Daytrana carries a boxed warning about cardiovascular risks. The patch can cause:
Patients with pre-existing heart conditions, structural cardiac abnormalities, or high blood pressure should be carefully evaluated before starting Daytrana.
Stimulant medications can cause or worsen psychiatric symptoms, including:
These symptoms are more likely in patients with a history of psychiatric disorders but can occur in anyone.
Long-term use of stimulant medications in children may slow growth. Regular monitoring of height and weight is recommended, and your doctor may suggest drug holidays to allow catch-up growth.
Daytrana can cause changes in blood flow to the fingers and toes, leading to numbness, pain, or color changes (pale, blue, or red). This condition is known as Raynaud's phenomenon. Report any circulation changes to your doctor.
When combined with serotonergic medications like SSRIs or SNRIs, Daytrana can contribute to serotonin syndrome — a potentially life-threatening condition. Symptoms include agitation, rapid heartbeat, high temperature, and muscle rigidity. Seek emergency medical care if these occur.
In rare cases, Daytrana may lower the seizure threshold. Patients with a history of seizures should be closely monitored.
Children are the only FDA-approved population for Daytrana. Growth suppression, appetite loss, and skin irritation are the most closely monitored side effects in this age group. Regular pediatric checkups should include height, weight, and cardiovascular monitoring.
Daytrana is classified as Pregnancy Category C, meaning it should only be used during pregnancy if the potential benefit justifies the risk. Methylphenidate is excreted in breast milk, so breastfeeding mothers should consult their doctor before using this medication.
Due to the boxed warning about cardiovascular events, patients with structural heart defects, coronary artery disease, serious heart rhythm problems, or uncontrolled high blood pressure should generally avoid Daytrana and other stimulant medications.
Here are practical strategies for dealing with common Daytrana side effects:
Every medication has potential side effects, and Daytrana is no exception. The most important thing is to stay informed, communicate openly with your doctor, and report any concerning symptoms promptly. While Daytrana is currently discontinued, understanding its side effect profile can help you evaluate alternative ADHD medications that share similar active ingredients.
If you're looking for an ADHD medication that's currently available, Medfinder can help you check pharmacy stock in your area.
You focus on staying healthy. We'll handle the rest.
Try Medfinder Concierge FreeMedfinder's mission is to ensure every patient gets access to the medications they need. We believe this begins with trustworthy information. Our core values guide everything we do, including the standards that shape the accuracy, transparency, and quality of our content. We’re committed to delivering information that’s evidence-based, regularly updated, and easy to understand. For more details on our editorial process, see here.
%2C%20Color%3DOriginal.png)
