Can't find Amoxicillin/Clavulanate (Augmentin)? Learn about safe, effective alternatives like Cefdinir, Cephalexin, Azithromycin, and Doxycycline.
You went to the doctor, got your prescription, and headed to the pharmacy — only to be told they don't have Amoxicillin/Clavulanate (Augmentin) in stock. It's a frustrating situation, but it doesn't mean you're out of options.
Depending on the type of infection you have, your doctor may be able to prescribe an alternative antibiotic that works just as well. In this guide, we'll explain what Amoxicillin/Clavulanate does, how it works, and which alternatives might be right for you.
Important: Never switch antibiotics on your own. Always talk to your doctor or pharmacist before taking a different medication than what was prescribed.
Amoxicillin/Clavulanate is a combination antibiotic that contains two active ingredients:
This combination makes Amoxicillin/Clavulanate effective against a broader range of bacteria than amoxicillin alone. It's commonly prescribed for sinus infections, ear infections, respiratory infections, urinary tract infections, skin infections, and dental infections.
The brand name is Augmentin, but most prescriptions are filled with the generic version. It comes in tablets (875/125 mg is the most common adult dose), chewable tablets, liquid suspension, and extended-release tablets.
Amoxicillin works by binding to proteins inside bacterial cell walls called penicillin-binding proteins (PBPs). This stops the bacteria from building and maintaining their protective cell walls, which ultimately kills them.
Some bacteria have learned to produce an enzyme called beta-lactamase that breaks down amoxicillin before it can work. That's where clavulanate comes in — it blocks beta-lactamase, allowing amoxicillin to do its job. This is why Amoxicillin/Clavulanate can treat infections that plain amoxicillin cannot.
If you can't find Amoxicillin/Clavulanate, your doctor may consider one of these alternatives. The best choice depends on the type of infection, your allergies, and your medical history.
Cefdinir is a third-generation cephalosporin antibiotic. It's one of the most common substitutes for Amoxicillin/Clavulanate, especially for:
Cefdinir is available as capsules and oral suspension. It's generally well-tolerated, with diarrhea being the most common side effect. Most people who are allergic to penicillin can safely take cephalosporins, but you should always inform your doctor about any allergies.
Typical cost: $10-$30 with a discount card for a generic course of treatment.
Cephalexin is a first-generation cephalosporin. It has a narrower spectrum than Amoxicillin/Clavulanate but is effective for many of the same conditions, including:
Cephalexin is very affordable — often under $10 with a discount card — and is widely available. It's taken 2-4 times per day depending on the infection.
Typical cost: $4-$15 with a discount card.
Azithromycin belongs to a completely different class of antibiotics called macrolides. It's a popular alternative for patients who are allergic to penicillin. Common uses include:
One advantage of Azithromycin is its convenient dosing — typically a 5-day course (the famous "Z-Pack"). It's generally well-tolerated, though it can cause nausea and diarrhea.
Typical cost: $8-$20 with a discount card.
Doxycycline is a tetracycline antibiotic with broad-spectrum activity. It's useful for:
Doxycycline should not be used in children under 8 years old or during pregnancy. It can cause sun sensitivity and stomach upset. Take it with plenty of water and avoid lying down for 30 minutes after.
Typical cost: $8-$25 with a discount card.
The best alternative depends on several factors:
Your doctor is the best person to make this decision. If your pharmacy is out of Amoxicillin/Clavulanate, ask them to contact your prescriber about switching to an available alternative.
Before switching medications, it's worth checking whether another pharmacy near you has Amoxicillin/Clavulanate in stock. Medfinder can help you search for pharmacies with current availability. You might also try independent pharmacies, which often have better stock during shortages.
For more tips, read our guide on how to find Amoxicillin/Clavulanate in stock near you.
Not being able to fill your Amoxicillin/Clavulanate prescription is stressful, especially when you're dealing with an infection. The good news is that effective alternatives exist for most conditions that Amoxicillin/Clavulanate treats. Talk to your doctor about switching if you can't find it, or use Medfinder to locate a pharmacy that has it in stock.
For more information about Amoxicillin/Clavulanate, check out our articles on uses, dosage, and what you need to know and side effects to watch for.
You focus on staying healthy. We'll handle the rest.
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