Alternatives to Adipex-P If You Can't Fill Your Prescription

You have a prescription for Adipex-P, but your pharmacy can't fill it. Maybe it's out of stock, maybe the cost is too high, or maybe your insurance won't cover it. Whatever the reason, you still need help managing your weight — and the good news is that you have options.

In this guide, we'll cover what Adipex-P is, how it works, and the best alternative medications your doctor might consider if Adipex-P isn't available to you.

What Is Adipex-P?

Adipex-P is a brand-name prescription medication containing Phentermine Hydrochloride 37.5 mg. It's manufactured by Teva Pharmaceuticals and has been FDA-approved for weight management since 1959.

It's prescribed for short-term use (typically a few weeks) in adults with a BMI of 30 or higher, or 27 or higher with at least one weight-related condition like high blood pressure, type 2 diabetes, or high cholesterol. For a complete overview, see our guide on what Adipex-P is and how to take it.

How Does Adipex-P Work?

Phentermine works by stimulating the release of norepinephrine in your brain. This triggers your "fight or flight" response, which naturally suppresses your appetite. The result: you feel less hungry, eat smaller portions, and take in fewer calories.

It's classified as a sympathomimetic amine — chemically related to amphetamines but with a much lower potential for abuse. That's why it's a Schedule IV controlled substance rather than the more restrictive Schedule II classification that drugs like Adderall carry.

For a deeper dive, read our article on how Adipex-P works.

Best Alternatives to Adipex-P

If you can't get Adipex-P filled, these are the most common alternatives your doctor may recommend. Each works differently, so the right choice depends on your health history, insurance coverage, and weight-loss goals.

1. Lomaira (Phentermine 8 mg)

What it is: Lomaira is a lower-dose form of the exact same drug in Adipex-P — Phentermine. Instead of one 37.5 mg dose in the morning, you take an 8 mg tablet three times a day, 30 minutes before meals.

Why consider it:

• Same active ingredient as Adipex-P
• Lower dose may mean fewer side effects like insomnia and jitteriness
• May be easier to find in stock since it's a different strength
• Generic versions are available

Typical cost: $15-$40 per month with a discount coupon for generic.

2. Qsymia (Phentermine/Topiramate)

What it is: Qsymia combines Phentermine with Topiramate (a medication originally used for seizures and migraines). This combination attacks weight from two angles — appetite suppression plus a feeling of fullness.

Why consider it:

• FDA-approved for long-term weight management (not just short-term like Adipex-P)
• Studies show greater weight loss than Phentermine alone — patients lost an average of 8-10% of body weight
• Available in multiple dose strengths for gradual titration

Typical cost: $150-$200 per month without insurance. Manufacturer coupons and insurance may significantly reduce this.

3. Contrave (Naltrexone/Bupropion)

What it is: Contrave is a combination of Naltrexone (used for addiction treatment) and Bupropion (an antidepressant also marketed as Wellbutrin). Together, they work on the brain's reward and hunger centers to reduce cravings and appetite.

Why consider it:

• Not a controlled substance — easier to prescribe and fill
• Good option for patients who also struggle with food cravings or emotional eating
• FDA-approved for long-term use
• Does not cause the stimulant side effects that Phentermine can

Typical cost: $99-$300 per month without insurance. Manufacturer savings programs may help.

4. Wegovy (Semaglutide)

What it is: Wegovy is a GLP-1 receptor agonist — a once-weekly injection that works by mimicking a natural hormone that regulates appetite and blood sugar. It's one of the most effective weight-loss medications available.

Why consider it:

• Patients lost an average of 15% of body weight in clinical trials
• Once-weekly injection — no daily pills
• Also shown to reduce cardiovascular risk
• FDA-approved for long-term weight management

Typical cost: $1,300+ per month without insurance. Many insurance plans now cover it, and manufacturer savings programs are available.

How to Choose the Right Alternative

Here are some things to discuss with your doctor:

• Budget: Generic Phentermine and Lomaira are the most affordable options. GLP-1 drugs like Wegovy are much more expensive.
• Duration: If you need longer-term treatment, Qsymia, Contrave, or Wegovy are approved for extended use. Adipex-P is only approved for short-term use.
• Side effects: If stimulant side effects bother you (insomnia, racing heart), Contrave or Wegovy may be better options.
• Health history: Your doctor will consider your full medical history, including heart conditions, mental health, and other medications you take. See our guide on Adipex-P drug interactions for more details.

Final Thoughts

Not being able to fill your Adipex-P prescription is frustrating, but it's not the end of the road. There are several effective alternatives, from lower-dose Phentermine (Lomaira) to newer medications like Wegovy. Talk to your doctor about which option makes the most sense for you.

In the meantime, use Medfinder to check if Adipex-P or generic Phentermine is available at a pharmacy near you. You might find it's back in stock sooner than you think. Also check out our guide on how to save money on Adipex-P if cost is a factor.